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Stock-Based Compensation (Details Narrative) - USD ($)
3 Months Ended
Feb. 19, 2019
Sep. 28, 2018
Mar. 31, 2021
Mar. 31, 2020
Dec. 31, 2020
Jun. 15, 2020
Weighted average exercise price, options granted     $ 2.24 $ 1.01    
Unrecognized compensation cost related to non-vested stock based compensation     $ 4,100,000      
Stock based compensation cost expected to be recognized, weighted average period     1 year 3 months 19 days      
Equity Stock Awards [Member] | Granted Under 2018 Plan and 2007 Plan [Member]            
Number of shares reserved for future issuance     6,420,825      
Inducement Awards [Member]            
Number of shares reserved for future issuance         140,004  
Stock Options and Restricted Stock Awards [Member]            
Compensation cost     $ 1,600,000 $ 500,000    
Stock Options and Restricted Stock Awards [Member] | Research and Development Expense [Member]            
Compensation cost     587,507 177,936    
Stock Options and Restricted Stock Awards [Member] | General and Administrative Expense [Member]            
Compensation cost     $ 991,819 $ 274,029    
2018 Stock Incentive Plan [Member]            
Equity awards, number of stock authorized     2,700,000      
Number of shares reserved for future issuance     6,498,424      
2018 Stock Incentive Plan [Member] | Minimum [Member]            
Number of equity awards available for future issuance     1,200,000     2,500,000
2018 Stock Incentive Plan [Member] | Maximum [Member]            
Number of equity awards available for future issuance     3,900,000     6,400,000
2007 Stock Incentive Plan [Member]            
Stock options, strike price description     Options are generally granted with strike prices equal to the fair market value of a share of Celsion common stock on the date of grant. Incentive stock options may be granted to purchase shares of common stock at a price not less than 100% of the fair market value of the underlying shares on the date of grant, provided that the exercise price of any incentive stock option granted to an eligible employee owning more than 10% of the outstanding stock of Celsion must be at least 110% of such fair market value on the date of grant. Only officers and key employees may receive incentive stock options.      
Inducement Option Grants [Member] | Five New Employees [Member]            
Weighted average exercise price, options granted $ 2.18 $ 2.77        
Option vested period 3 years 3 years        
Inducement Option Grants [Member] | Five New Employees [Member] | Restricted Stock [Member]            
Number of shares issued 13,000 19,000        
Inducement Option Grants [Member] | Five New Employees [Member] | Common Stock Outstanding [Member]            
Number of shares issued 140,004 164,004        
2018 Plan [Member]            
Number of shares reserved for future issuance         77,599