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Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
3 Months Ended 6 Months Ended 12 Months Ended
Jun. 30, 2021
Jun. 30, 2020
Jun. 30, 2021
Jun. 30, 2020
Dec. 31, 2020
Cash flows from operating activities:          
Net loss $ (5,448,397) $ (5,342,935) $ (11,137,400) $ (10,399,813)  
Adjustments to reconcile net loss to net cash used in operating activities:          
Depreciation and amortization     383,801 378,990  
Change in fair value of earn-out milestone liability (81,000) 256,296 70,000 297,570  
Recognition of deferred revenue     (250,000) (250,000)  
Stock-based compensation costs     2,372,945 1,030,726  
Deferred income tax asset     1,845,823 1,819,324  
Amortization of deferred finance charges and debt discount associated with notes payable     145,884 192,793  
Net changes in:          
Accrued interest on investment securities     (105,000) 13,503  
Advances, deposits, and other current assets     (183,756) (60,104)  
Accounts payable and accrued liabilities     (491,694) (946,265)  
Net cash used in operating activities     (7,349,397) (7,923,276)  
Cash flows from investing activities:          
Purchases of investment securities     (40,927,055) (9,940,894)  
Proceeds from sale and maturity of investment securities     9,000,000 15,100,000  
Purchases of property and equipment     (227,000) (11,837)  
Net cash (used in) provided by investing activities     (32,154,055) 5,147,269  
Cash flows from financing activities:          
Proceeds from sale of common stock equity, net of issuance costs     52,697,265 18,182,599  
Proceeds from issuance of common stock upon conversion of stock warrants     1,508,666  
Proceeds from issuance of common stock upon conversion of stock options     4,725 371,895  
Proceeds from the SVB Loan Facility, net of issuance costs     5,756,630  
Payoff of the Horizon Credit Agreement and accrued end of term fees     (5,190,587)  
Proceeds from Payroll Protection Program (PPP) loans     1,324,750  
Repayments on Payroll Protection Program (PPP) loans     (1,324,750)  
Net cash provided by financing activities     54,776,699 18,554,494  
Increase in cash, cash equivalents and restricted cash     15,273,247 15,778,487  
Cash, cash equivalents and restricted cash at beginning of period     17,164,177 6,875,273 $ 6,875,273
Cash, cash equivalents and restricted cash at end of period $ 32,437,424 $ 22,653,760 32,437,424 22,653,760 $ 17,164,177
Supplemental disclosures of cash flow information:          
Interest paid     (267,360) (487,174)  
Cash paid for amounts included in measurement of lease liabilities:          
Operating cash flows from lease payments     264,546 262,084  
Common stock issued to settle accrued bonuses     498,632  
Realized and unrealized gains (losses), net, on investment securities     $ 3,770 $ (34,912)