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v3.22.1

Consolidated Statements of Cash Flows - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020
Cash flows from operating activities: |  |
Net loss | $ (20,769,250) | $ (21,483,561)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Depreciation and amortization | 702,918 | 741,524
Change in fair value of earn-out milestone liability | (1,622,000) | 1,300,291
Fair value of warrants issued in exchange for services |  | 44,798
Stock-based compensation | 3,759,737 | 1,851,391
Change in deferred income tax asset | 462,377 | (26,499)
Impairment of goodwill and in-process research and development | 1,976,101 | 2,370,257
Amortization of deferred finance charges and debt discount associated with note payable | 237,258 | 447,483
Net changes in: |  |
Accrued interest receivable on investment securities | (108,844) | 21,369
Advances and deposits on clinical programs and other current assets | (786,718) | (308,025)
Other assets | (124,728) | 274,513
Accounts payable – trade | 302,404 | (618,102)
Deferred revenue | (500,000) | (500,000)
Other accrued liabilities | 247,142 | 265,885
Net cash used in operating activities | (16,223,603) | (15,618,676)
Cash flows from investing activities: |  |
Purchases of investment in debt securities | (53,811,069) | (9,956,892)
Proceeds from sale and maturity of investment in debt securities | 24,000,000 | 17,900,000
Purchases of property and equipment | (311,613) | (19,092)
Net cash (used in) provided by investing activities | (30,122,682) | 7,924,016
Cash flows from financing activities: |  |
Proceeds from issuance of common stock equity, net of issuance costs | 52,688,946 | 22,811,669
Proceeds from issuance of common stock upon exercise of warrants | 1,508,666 |
Proceeds from issuance of common stock upon exercise of stock options | 4,725 | 371,895
Proceeds from notes payable | 5,756,630 |
Payments on notes payable including end-of-term fees | (5,190,587) | (5,200,000)
Proceeds from Paycheck Protection Program (“PPP”) loans |  | 1,324,750
Repayments on PPP loans |  | (1,324,750)
Net cash provided by financing activities | 54,768,380 | 17,983,564
Change in cash, cash equivalents and restricted cash | 8,422,095 | 10,288,904
Cash, cash equivalents and restricted cash at beginning of year | 17,164,177 | 6,875,273
Cash, cash equivalents and restricted cash at end of year | 25,586,272 | 17,164,177
Supplemental disclosures of cash flow information: |  |
Interest | (357,277) | (844,278)
Cash paid for amounts included in measurement of lease liabilities: |  |
Operating cash flows from lease payments | 568,269 | 525,809
Non-cash financing and investing activities |  |
Common stock issued to settle accrued bonuses |  | 498,632
Fair value of warrants issued in connection with the debt facility, net of cancelled warrants |  | 81,102
Realized and unrealized losses (gains), net, on investment in debt securities | $ 7,974 | $ (42,778)

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