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Consolidated Statements of Changes in Stockholders' Equity - USD ($)
Common Stock [Member]
Additional Paid-in Capital [Member]
Treasury Stock [Member]
AOCI Attributable to Parent [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2019 $ 15,504 $ 305,102,721 $ (85,188) $ 42,778 $ (290,516,780) $ 14,559,035
Beginning balance, shares at Dec. 31, 2019 1,550,388   22      
Net loss (21,483,561) (21,483,561)
Sale of equity through equity financing facilities $ 11,116 22,800,553 22,811,669
Sale of equity through equity financing facilities, shares 1,111,615          
Issuance of common stock upon exercise of options and vesting of stock awards $ 96 371,799 371,895
Issuance of common stock upon exercise of options and vesting of stock awards, shares 9,591          
Issuance of common stock upon exercise of common stock warrants $ 132 (132)
Issuance of common stock upon exercise of common stock warrants,shares 13,151          
Common stock issued to settle accrued bonuses $ 286 498,346 498,632
Common stock issued to settle accrued bonuses, shares 28,657          
Common stock warrants issued in exchange for services 44,798 44,798
Stock-based compensation expense 1,851,391 1,851,391
Realized and unrealized gains and losses, net, on investment securities (42,778) (42,778)
Ending balance, value at Dec. 31, 2020 $ 27,134 330,669,476 $ (85,188) (312,000,341) 18,611,081
Ending balance, shares at Dec. 31, 2020 2,713,402   22      
Net loss (20,769,250) (20,769,250)
Sale of equity through equity financing facilities $ 29,755 52,659,191 52,688,946
Sale of equity through equity financing facilities, shares 2,975,503          
Issuance of common stock upon exercise of options $ 5 4,720 4,725
Issuance of common stock upon exercise of options, shares 500          
Shares issued pursuant to warrant exercises $ 811 1,507,855 1,508,666
Shares issued pursuant to warrant exercises, shares 81,111          
Stock-based compensation expense 3,759,737 3,759,737
Realized and unrealized gains and losses, net, on investment securities (7,974) (7,974)
Ending balance, value at Dec. 31, 2021 $ 57,705 $ 388,600,979 $ (85,188) $ (7,974) $ (332,769,591) $ 55,795,931
Ending balance, shares at Dec. 31, 2021 5,770,516   22