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Summary of Stock Option Awards and Restricted Stock Grants (Details) - USD ($)	3 Months Ended
	Mar. 31, 2022	Mar. 31, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average exercise price, granted	$ 4.16	$ 2.03
Weighted average contractual terms, exercisable	7 years 6 months
Share-Based Payment Arrangement, Option [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options outstanding, beginning balance	441,425
Weighted average exercise price, beginning balance	$ 38.49
Options outstanding, granted	224,276
Weighted average exercise price, granted	$ 4.60
Options outstanding, ending balance	665,701
Weighted average exercise price, ending balance	$ 27.07
Weighted average contractual terms	8 years
Options outstanding, aggregate intrinsic value	$ 103,167
Options outstanding, exercisable	419,559
Weighted average exercise price, exercisable	$ 33.22
Options outstanding, aggregate intrinsic value, exercisable	$ 34,304
Restricted Stock [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Non-vested stock awards, beginning balance	1,481
Weighted average grant date fair value, beginning balance	$ 12.36
Non-vested stock awards, granted	400
Weighted average grant date fair value, granted	$ 4.60
Non-vested stock awards, ending balance	1,881
Weighted average grant date fair value, ending balance	$ 10.71
Non-vested stock awards, aggregate intrinsic value	$ 20,145

X

- Definition

The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (c)(2)(iii)(01)
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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
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The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
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Per share or unit weighted-average fair value of nonvested award under share-based payment arrangement. Excludes share and unit options.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

+ References

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

+ References

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Net number of share options (or share units) granted during the period.

+ References

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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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- Definition

Intrinsic value of outstanding award under share-based payment arrangement. Excludes share and unit options.

+ References

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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