Summary of Stock Option Awards and Restricted Stock Grants (Details) - USD ($)	9 Months Ended
Sep. 30, 2022	Sep. 30, 2021
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Weighted average exercise price, granted	$ 2.23	$ 1.97
Weighted average contractual terms, exercisable	7 years 6 months
Share-Based Payment Arrangement, Option [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Options outstanding, beginning balance	441,425
Weighted average exercise price, beginning balance	$ 38.50
Options outstanding, granted	697,156
Weighted average exercise price, granted	$ 2.79
Options outstanding, Terminated	(17,659)
Weighted average exercise price, Terminated	$ 35.28
Options outstanding, ending balance	1,120,922
Weighted average exercise price, ending balance	$ 16.33
Weighted average contractual terms	8 years 1 month 6 days
Options outstanding, aggregate intrinsic value	$ 335
Options outstanding, exercisable	521,723
Weighted average exercise price, exercisable	$ 27.72
Options outstanding, aggregate intrinsic value, exercisable
Restricted Stock [Member]
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]
Non-vested stock awards, beginning balance	1,481
Weighted average grant date fair value, beginning balance	$ 12.36
Non-vested stock awards, granted	55,650
Weighted average grant date fair value, granted	$ 1.96
Non-vested stock awards, Terminated	(100)
Weighted average grant date fair value, Terminated	$ 9.45
Non-vested stock awards, ending balance	57,031
Weighted average grant date fair value, ending balance	$ 2.23
Non-vested stock awards, aggregate intrinsic value

The number of equity-based payment instruments, excluding stock (or unit) options, that were forfeited during the reporting period.

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Weighted average fair value as of the grant date of equity-based award plans other than stock (unit) option plans that were not exercised or put into effect as a result of the occurrence of a terminating event.

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The number of grants made during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The weighted average fair value at grant date for nonvested equity-based awards issued during the period on other than stock (or unit) option plans (for example, phantom stock or unit plan, stock or unit appreciation rights plan, performance target plan).

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The number of non-vested equity-based payment instruments, excluding stock (or unit) options, that validly exist and are outstanding as of the balance sheet date.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
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-Subparagraph (c)(2)(ii)
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Per share or unit weighted-average fair value of nonvested award under share-based payment arrangement. Excludes share and unit options.

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Line items represent financial concepts included in a table. These concepts are used to disclose reportable information associated with domain members defined in one or many axes to the table.

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No definition available.

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The number of shares into which fully or partially vested stock options outstanding as of the balance sheet date can be currently converted under the option plan.

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The weighted-average price as of the balance sheet date at which grantees can acquire the shares reserved for issuance on vested portions of options outstanding and currently exercisable under the stock option plan.

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The number of shares under options that were cancelled during the reporting period as a result of occurrence of a terminating event specified in contractual agreements pertaining to the stock option plan.

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Net number of share options (or share units) granted during the period.

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Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef
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Amount by which the current fair value of the underlying stock exceeds the exercise price of options outstanding.

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Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef
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- Definition

Number of options outstanding, including both vested and non-vested options.

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Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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Weighted average price at which grantees could have acquired the underlying shares with respect to stock options that were terminated.

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Weighted average per share amount at which grantees can acquire shares of common stock by exercise of options.

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Intrinsic value of outstanding award under share-based payment arrangement. Excludes share and unit options.

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Amount of difference between fair value of the underlying shares reserved for issuance and exercise price of vested portions of options outstanding and currently exercisable.

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Weighted average remaining contractual term for vested portions of options outstanding and currently exercisable or convertible, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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Weighted average remaining contractual term for option awards outstanding, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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