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Stock-Based Compensation (Details Narrative) - USD ($)
$ / shares in Units, $ in Millions
3 Months Ended 9 Months Ended
Sep. 27, 2022
Jul. 19, 2022
Feb. 19, 2019
Sep. 28, 2018
Sep. 30, 2022
Sep. 30, 2021
Sep. 30, 2022
Sep. 30, 2021
Jun. 10, 2021
Jun. 15, 2020
May 14, 2019
May 15, 2018
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Options granted, weighted average exercise price             $ 2.23 $ 1.97        
Unrecognized share based compensation         $ 1.9   $ 1.9          
Unrecognized share based compensation, period             4 years          
Inducement Awards [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Common stock, reserved for future issuance         194,837   194,837          
Equity Stock Awards [Member] | Granted Under 2018 Plan and 2007 Plan [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Common stock, reserved for future issuance         926,085   926,085          
Stock Options and Restricted Stock Awards [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based compensation         $ 0.4 $ 0.7 $ 2.0 $ 3.1        
Stock Options and Restricted Stock Awards [Member] | Research and Development Expense [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based compensation         0.1 0.2 0.7 1.1        
Stock Options and Restricted Stock Awards [Member] | General and Administrative Expense [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based compensation         $ 0.3 $ 0.5 $ 1.3 $ 2.0        
Common Stock [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Shares issued, shares             1,328,274 2,975,503        
2018 Stock Incentive Plan [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share-based payment award, shares authorized                       180,000
Common stock, reserved for future issuance         946,454   946,454          
2018 Stock Incentive Plan [Member] | Minimum [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based payment award, shares granted                 513,333 166,667 80,000  
2018 Stock Incentive Plan [Member] | Maximum [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based payment award, shares granted                 940,000 426,667 260,000  
2007 Stock Incentive Plan [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Stock options, strike price description             Options are generally granted with strike prices equal to the fair market value of a share of common stock on the date of grant. Incentive stock options may be granted to purchase shares of common stock at a price not less than 100% of the fair market value of the underlying shares on the date of grant, provided that the exercise price of any incentive stock option granted to an eligible employee owning more than 10% of the outstanding stock of the Company must be at least 110% of such fair market value on the date of grant. Only officers and key employees may receive incentive stock options.          
Inducement Option Grants [Member] | Eight New Employees [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Options granted, weighted average exercise price $ 1.65 $ 1.95 $ 32.70 $ 41.55                
Inducement Option Grants [Member] | Eight New Employees [Member] | Restricted Stock [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Shares issued, shares 2,250 53,000 8,666 1,266                
Inducement Option Grants [Member] | Eight New Employees [Member] | Common Stock [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Shares issued, shares 8,501 177,000 4,668 4,668                
Inducement Option Grants [Member] | Minimum [Member] | Eight New Employees [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based payment award vesting period     3 years                  
Inducement Option Grants [Member] | Maximum [Member] | Eight New Employees [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Share based payment award vesting period     4 years                  
2018 Plan [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Common stock, reserved for future issuance         18,088   18,088          
2007 Plan [Member]                        
Share-Based Compensation Arrangement by Share-Based Payment Award [Line Items]                        
Common stock, reserved for future issuance         18,088   18,088