    <SEC-DOCUMENT>0001213900-19-006662-index.html : 20190418
    <SEC-HEADER>0001213900-19-006662.hdr.sgml : 20190418
    <ACCEPTANCE-DATETIME>20190418151628
    ACCESSION NUMBER:		0001213900-19-006662
    CONFORMED SUBMISSION TYPE:	POS AM
    PUBLIC DOCUMENT COUNT:		19
    FILED AS OF DATE:		20190418
    DATE AS OF CHANGE:		20190418

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Aptorum Group Ltd
    		CENTRAL INDEX KEY:			0001734005
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			E9
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		POS AM
    		SEC ACT:		1933 Act
    		SEC FILE NUMBER:	333-227198
    		FILM NUMBER:		19755705

    	BUSINESS ADDRESS:
    		STREET 1:		17/F, GUANGDONG INVESTMENT TOWER
    		STREET 2:		148 CONNAUGHT ROAD CENTRAL
    		CITY:			HONG KONG
    		STATE:			F4
    		ZIP:			999077
    		BUSINESS PHONE:		852 2117 6611

    	MAIL ADDRESS:
    		STREET 1:		17/F, GUANGDONG INVESTMENT TOWER
    		STREET 2:		148 CONNAUGHT ROAD CENTRAL
    		CITY:			HONG KONG
    		STATE:			F4
    		ZIP:			999077
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>POS AM
    <SEQUENCE>1
    <FILENAME>posam2019a1_aptorumgroup.htm
    <DESCRIPTION>POST-EFFECTIVE AMENDMENT NO. 1 TO FORM F-1
    <TEXT>
    Document 1 - file: posam2019a1_aptorumgroup.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.1
    <SEQUENCE>2
    <FILENAME>posam2019a1ex5-1_aptorum.htm
    <DESCRIPTION>OPINION OF CAYMAN ISLANDS COUNSEL OF APTORUM GROUP LIMITED, AS TO THE VALIDITY OF THE ORDINARY SHARES AND TAX MATTERS
    <TEXT>
    Document 2 - file: posam2019a1ex5-1_aptorum.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-5.2
    <SEQUENCE>3
    <FILENAME>posam2019a1ex5-2_aptorum.htm
    <DESCRIPTION>OPINION OF U.S. COUNSEL OF APTORUM GROUP LIMITED, AS TO THE BINDING OBLIGATION OF THE UNDERWRITER WARRANTS UNDER THE LAWS OF THE STATE OF NEW YORK
    <TEXT>
    Document 3 - file: posam2019a1ex5-2_aptorum.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>EX-23.1
    <SEQUENCE>4
    <FILENAME>posam2019a1ex23-1_aptorum.htm
    <DESCRIPTION>CONSENT OF MARCUM BERNSTEIN & PINCHUK LLP
    <TEXT>
    Document 4 - file: posam2019a1ex23-1_aptorum.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>img_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: img_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>img_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: img_002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>img_003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 7 - file: img_003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>img_004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 8 - file: img_004.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>img_005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 9 - file: img_005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>img_006.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 10 - file: img_006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>img_007.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 11 - file: img_007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>img_008.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: img_008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>13
    <FILENAME>img_009.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 13 - file: img_009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>14
    <FILENAME>img_010.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 14 - file: img_010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>15
    <FILENAME>img_011.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 15 - file: img_011.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>16
    <FILENAME>ex5-2_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 16 - file: ex5-2_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>17
    <FILENAME>img_012.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 17 - file: img_012.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>18
    <FILENAME>ex23-1_001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 18 - file: ex23-1_001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>19
    <FILENAME>ex23-1_002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 19 - file: ex23-1_002.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>