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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2012 | $ 99,785 | $ 50,580,400 | $ (52,113,313) | $ (1,433,128)
Beginning balance, shares at Dec. 31, 2012 | 99,784,982 |  |  |
Shares issued in offerings, net of cost | $ 45,117 | 78,605,236 |  | 78,650,353
Shares issued in offerings, net of cost, shares | 45,116,352 |  |  |
Shares issued for exercise of options | $ 75 | 30,835 |  | $ 30,910
Shares issued for exercise of options, shares | 75,423 |  |  | 75,423
Share-based Compensation |  | 3,254,083 |  | $ 3,254,083
Warrants issued for financing costs |  | 1,711,956 |  | 1,711,956
Warrants issued for services |  | 867,262 |  | 867,262
Warrants issued as compensation-related party |  | 36,284 |  | 36,284
Net loss |  |  | (28,419,313) | (28,419,313)
Ending balance at Dec. 31, 2013 | $ 144,977 | 135,086,056 | (80,532,626) | $ 54,698,407
Ending balance, shares at Dec. 31, 2013 | 144,976,757 |  |  | 144,976,757
Shares issued in offerings, net of cost | $ 9,850 | 42,761,503 |  | $ 42,771,353
Shares issued in offerings, net of cost, shares | 9,850,106 |  |  |
Shares issued for exercise of options | $ 855 | 344,891 |  | 345,746
Shares issued for exercise of options, shares | 854,573 |  |  |
Shares issued in exercise of warrants | $ 365 | 180,635 |  | 181,000
Shares issued in exercise of warrants, shares | 365,583 |  |  |
Shares issued for exercise of restricted stock units | $ 50 | (50) |  |
Shares issued for exercise of restricted stock units, shares | 50,000 |  |  |
Share-based Compensation |  | 4,609,811 |  | 4,609,811
Net loss |  |  | (54,217,210) | (54,217,210)
Ending balance at Dec. 31, 2014 | $ 156,097 | 182,982,846 | (134,749,836) | $ 48,389,107
Ending balance, shares at Dec. 31, 2014 | 156,097,019 |  |  | 156,097,019
Shares issued in offerings, net of cost | $ 20,040 | 91,354,609 |  | $ 91,374,649
Shares issued in offerings, net of cost, shares | 20,040,359 |  |  |
Shares issued for exercise of options | $ 613 | 1,231,966 |  | 1,232,579
Shares issued for exercise of options, shares | 612,981 |  |  |
Shares issued in exercise of warrants | $ 1,178 | 364,822 |  | 366,000
Shares issued in exercise of warrants, shares | 1,177,682 |  |  |
Share-based Compensation |  | 6,777,835 |  | 6,777,835
Net loss |  |  | (85,077,024) | (85,077,024)
Ending balance at Dec. 31, 2015 | $ 177,928 | $ 282,712,078 | $ (219,826,860) | $ 63,063,146
Ending balance, shares at Dec. 31, 2015 | 177,928,041 |  |  | 177,928,041

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