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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Common Stock [Member]
Additional Paid in Capital [Member]
Accumulated Deficit [Member]
Total
Beginning balance at Dec. 31, 2012 $ 99,785 $ 50,580,400 $ (52,113,313) $ (1,433,128)
Beginning balance, shares at Dec. 31, 2012 99,784,982      
Shares issued in offerings, net of cost $ 45,117 78,605,236   78,650,353
Shares issued in offerings, net of cost, shares 45,116,352      
Shares issued for exercise of options $ 75 30,835   $ 30,910
Shares issued for exercise of options, shares 75,423     75,423
Share-based Compensation   3,254,083   $ 3,254,083
Warrants issued for financing costs   1,711,956   1,711,956
Warrants issued for services   867,262   867,262
Warrants issued as compensation-related party   36,284   36,284
Net loss     (28,419,313) (28,419,313)
Ending balance at Dec. 31, 2013 $ 144,977 135,086,056 (80,532,626) $ 54,698,407
Ending balance, shares at Dec. 31, 2013 144,976,757     144,976,757
Shares issued in offerings, net of cost $ 9,850 42,761,503   $ 42,771,353
Shares issued in offerings, net of cost, shares 9,850,106      
Shares issued for exercise of options $ 855 344,891   345,746
Shares issued for exercise of options, shares 854,573      
Shares issued in exercise of warrants $ 365 180,635   181,000
Shares issued in exercise of warrants, shares 365,583      
Shares issued for exercise of restricted stock units $ 50 (50)    
Shares issued for exercise of restricted stock units, shares 50,000      
Share-based Compensation   4,609,811   4,609,811
Net loss     (54,217,210) (54,217,210)
Ending balance at Dec. 31, 2014 $ 156,097 182,982,846 (134,749,836) $ 48,389,107
Ending balance, shares at Dec. 31, 2014 156,097,019     156,097,019
Shares issued in offerings, net of cost $ 20,040 91,354,609   $ 91,374,649
Shares issued in offerings, net of cost, shares 20,040,359      
Shares issued for exercise of options $ 613 1,231,966   1,232,579
Shares issued for exercise of options, shares 612,981      
Shares issued in exercise of warrants $ 1,178 364,822   366,000
Shares issued in exercise of warrants, shares 1,177,682      
Share-based Compensation   6,777,835   6,777,835
Net loss     (85,077,024) (85,077,024)
Ending balance at Dec. 31, 2015 $ 177,928 $ 282,712,078 $ (219,826,860) $ 63,063,146
Ending balance, shares at Dec. 31, 2015 177,928,041     177,928,041