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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2013 | $ 144,977 | $ 135,086,056 | $ (80,532,626) | $ 54,698,407
Beginning balance (in shares) at Dec. 31, 2013 | 144,976,757 |  |  |
Increase (Decrease) in Stockholders' Deficiency [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 9,850 | 42,761,503 |  | 42,771,353
Shares issued in offerings, net of cost (in shares) | 9,850,106 |  |  |
Shares issued for exercise of options, net | $ 855 | 344,891 |  | 345,746
Shares issued for exercise of options, net (in shares) | 854,573 |  |  |
Shares issued for exercise of warrants, net | $ 365 | 180,635 |  | 181,000
Shares issued for exercise of warrants, net (in shares) | 365,583 |  |  |
Shares issued for exercise of restricted stock units | $ 50 | (50) |  |
Shares issued for exercise of restricted stock units (in shares) | 50,000 |  |  |
Share-based compensation |  | 4,609,811 |  | 4,609,811
Net loss |  |  | (54,217,210) | (54,217,210)
Ending balance at Dec. 31, 2014 | $ 156,097 | 182,982,846 | (134,749,836) | 48,389,107
Ending balance (in shares) at Dec. 31, 2014 | 156,097,019 |  |  |
Increase (Decrease) in Stockholders' Deficiency [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 20,040 | 91,354,609 |  | 91,374,649
Shares issued in offerings, net of cost (in shares) | 20,040,359 |  |  |
Shares issued for exercise of options, net | $ 613 | 1,231,966 |  | 1,232,579
Shares issued for exercise of options, net (in shares) | 612,981 |  |  |
Shares issued for exercise of warrants, net | $ 1,178 | 364,822 |  | 366,000
Shares issued for exercise of warrants, net (in shares) | 1,177,682 |  |  |
Share-based compensation |  | 6,777,835 |  | 6,777,835
Net loss |  |  | (85,077,024) | (85,077,024)
Ending balance at Dec. 31, 2015 | $ 177,928 | 282,712,078 | (219,826,860) | $ 63,063,146
Ending balance (in shares) at Dec. 31, 2015 | 177,928,041 |  |  | 177,928,041
Increase (Decrease) in Stockholders' Deficiency [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 17,424 | 134,846,051 |  | $ 134,863,475
Shares issued in offerings, net of cost (in shares) | 17,424,242 |  |  |
Shares issued for exercise of options, net | $ 613 | 988,447 |  | 989,060
Shares issued for exercise of options, net (in shares) | 613,195 |  |  |
Shares issued for exercise of warrants, net | $ 723 | 1,372,277 |  | 1,373,000
Shares issued for exercise of warrants, net (in shares) | 722,744 |  |  |
Share-based compensation |  | 17,076,199 |  | 17,076,199
Net loss |  |  | (89,875,459) | (89,875,459)
Ending balance at Dec. 31, 2016 | $ 196,688 | $ 436,995,052 | $ (309,702,319) | $ 127,489,421
Ending balance (in shares) at Dec. 31, 2016 | 196,688,222 |  |  | 196,688,222

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