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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($)
Common Stock
Additional Paid in Capital
Accumulated Deficit
Total
Beginning balance at Dec. 31, 2014 $ 156,097 $ 182,982,846 $ (134,749,836) $ 48,389,107
Beginning balance (in shares) at Dec. 31, 2014 156,097,019      
Shares issued in offerings, net of cost $ 20,040 91,354,609   91,374,649
Shares issued in offerings, net of cost (in shares) 20,040,359      
Shares issued for exercise of options, net $ 613 1,231,966   1,232,579
Shares issued for exercise of options, net (in shares) 612,981      
Shares issued for exercise of warrants, net $ 1,178 364,822   366,000
Shares issued for exercise of warrants, net (in shares) 1,177,682      
Share-based compensation   6,777,835   6,777,835
Net loss     (85,077,024) (85,077,024)
Ending balance at Dec. 31, 2015 $ 177,928 282,712,078 (219,826,860) 63,063,146
Ending balance (in shares) at Dec. 31, 2015 177,928,041      
Shares issued in offerings, net of cost $ 17,424 134,846,051   134,863,475
Shares issued in offerings, net of cost (in shares) 17,424,242      
Shares issued for exercise of options, net $ 613 988,447   989,060
Shares issued for exercise of options, net (in shares) 613,195      
Shares issued for exercise of warrants, net $ 723 1,372,277   1,373,000
Shares issued for exercise of warrants, net (in shares) 722,744      
Share-based compensation   17,076,199   17,076,199
Net loss     (89,875,459) (89,875,459)
Ending balance at Dec. 31, 2016 $ 196,688 436,995,052 (309,702,319) $ 127,489,421
Ending balance (in shares) at Dec. 31, 2016 196,688,222     196,688,222
Adoption of ASU 2016-09 at Dec. 31, 2016   31,421 (31,421)  
Shares issued in offerings, net of cost $ 12,400 68,560,235   $ 68,572,635
Shares issued in offerings, net of cost (in shares) 12,400,000      
Shares issued for exercise of options, net $ 103 212,512   212,615
Shares issued for exercise of options, net (in shares) 102,546      
Shares issued for exercise of warrants, net $ 7,239 3,791,760   3,798,999
Shares issued for exercise of warrants, net (in shares) 7,238,874      
Share-based compensation   6,760,425   6,760,425
Net loss     (76,925,380) (76,925,380)
Ending balance at Dec. 31, 2017 $ 216,430 $ 516,351,405 $ (386,659,120) $ 129,908,715
Ending balance (in shares) at Dec. 31, 2017 216,429,642     216,429,642