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STOCKHOLDERS' EQUITY (Details Narrative 3) - USD ($) |  |  |  |  | 3 Months Ended | 9 Months Ended |
--- | --- | --- | --- | --- | --- | --- | ---
Sep. 28, 2017 | Sep. 25, 2017 | Aug. 06, 2017 | Aug. 01, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Sep. 30, 2018 | Sep. 30, 2017 | Dec. 31, 2017
Share-based compensation expense |  |  |  |  | $ 2,109,218 | $ 1,885,050 | $ 5,981,343 | $ 4,691,735 |
Total unrecognized estimated compensation expense |  |  |  |  | $ 14,203,000 |  | $ 14,203,000 |  |
Recognized weighted-average period |  |  |  |  |  |  | 2 years 2 months 12 days |  |
Underwriting Agreement [Member] | Goldman Sachs & Co. LLC, [Member] |  |  |  |  |  |  |  |  |
Issue of common stock (in shares) |  |  |  | 12,745,098 |  |  |  |  |
Issue of common stock (in dollars per shares) |  |  |  | $ 5.10 |  |  |  |  |
Common stock exercisable shares |  |  |  | 1,911,764 |  |  |  |  |
Stock exercisable period |  |  |  | 30 days |  |  |  |  |
Net Proceeds |  |  |  | $ 69,908,000 |  |  |  |  |
Underwriting Agreement [Member] | J.P. Morgan Securities LLC [Member] |  |  |  |  |  |  |  |  |
Issue of common stock (in shares) | 12,400,000 | 12,400,000 |  |  |  |  |  |  |
Issue of common stock (in dollars per shares) |  | $ 5.55 |  |  |  |  |  |  |
Net Proceeds |  | $ 68,573,000 |  |  |  |  |  |  |
Knight License Agreement [Member] | Knight Therapeutics Inc. [Member] |  |  |  |  |  |  |  |  |
Issue of common stock value |  |  | $ 20,000,000 |  |  |  |  |  |
Stock Options [Member] |  |  |  |  |  |  |  |  |
Options outstanding, ending |  |  |  |  | 24,837,349 |  | 24,837,349 |  | 23,365,225
Weighted average grant date fair value per share of options granted |  |  |  |  |  |  | $ 3.27 | $ 3.82 |
Options outstanding |  |  |  |  | $ 4.15 |  | 4.15 |  | $ 3.78
Stock Options [Member] | Minimum [Member] |  |  |  |  |  |  |  |  |
Option exercise prices (in dollars per shares) |  |  |  |  | 0.10 |  | 0.10 |  |
Stock Options [Member] | Maximum [Member] |  |  |  |  |  |  |  |  |
Option exercise prices (in dollars per shares) |  |  |  |  | $ 8.92 |  | $ 8.92 |  |
Cash-Settled Stock Appreciation Rights (SARs) [Member] |  |  |  |  |  |  |  |  |
Options outstanding, ending |  |  |  |  | 106,000 |  | 106,000 |  |
Options outstanding |  |  |  |  | $ 1.36 |  | $ 1.36 |  |
2012 Stock Incentive Plan [Member] |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance |  |  |  |  | 10,000,000 |  | 10,000,000 |  |
Number of shares available for issuance |  |  |  |  | 3,473,333 |  | 3,473,333 |  |
2009 Long Term Incentive Compensation Plan [Member] |  |  |  |  |  |  |  |  |
Number of shares authorized for issuance |  |  |  |  | 25,000,000 |  | 25,000,000 |  |
Number of shares available for issuance |  |  |  |  | 900,037 |  | 900,037 |  |
Warrants [Member] |  |  |  |  |  |  |  |  |
Recognized weighted-average period |  |  |  |  |  |  | 6 months |  |
Warrants [Member] | Individuals [Member] |  |  |  |  |  |  |  |  |
Shares issued for exercise of warrants, net |  |  |  |  |  |  |  | $ 3,798,999 |
Shares issued for exercise of warrants, net (in shares) |  |  |  |  |  |  |  | 2,476,666 |

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