Represent common stock exercisable shares.

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- Definition

The exercise price of the option.

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No definition available.

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- Definition

The period the underwriter's option is exercisable to puechase additional scommon shares.

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No definition available.

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- Definition

Number of new stock issued during the period.

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No definition available.

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- Definition

Equity impact of the value of new stock issued during the period. Includes shares issued in an initial public offering or a secondary public offering.

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- Definition

Represents the expense recognized during the period arising from equity-based compensation arrangements (for example, shares of stock, unit, stock options or other equity instruments) with employees, directors and certain consultants qualifying for treatment as employees.

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- Definition

Weighted average period over which unrecognized compensation is expected to be recognized for equity-based compensation plans, in 'PnYnMnDTnHnMnS' format, for example, 'P1Y5M13D' represents the reported fact of one year, five months, and thirteen days.

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- Definition

Unrecognized cost of unvested options awarded to employees as compensation.

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- Definition

The cash inflow associated with the amount received from entity's first offering of stock to the public.

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The maximum number of shares (or other type of equity) originally approved (usually by shareholders and board of directors), net of any subsequent amendments and adjustments, for awards under the equity-based compensation plan. As stock or unit options and equity instruments other than options are awarded to participants, the shares or units remain authorized and become reserved for issuance under outstanding awards (not necessarily vested).

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The difference between the maximum number of shares (or other type of equity) authorized for issuance under the plan (including the effects of amendments and adjustments), and the sum of: 1) the number of shares (or other type of equity) already issued upon exercise of options or other equity-based awards under the plan; and 2) shares (or other type of equity) reserved for issuance on granting of outstanding awards, net of cancellations and forfeitures, if applicable.

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- Definition

The weighted average grant-date fair value of options granted during the reporting period as calculated by applying the disclosed option pricing methodology.

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- Definition

Number of options outstanding, including both vested and non-vested options.

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- Definition

Weighted average price at which grantees can acquire the shares reserved for issuance under the stock option plan.

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- Definition

Per share or per unit amount of equity securities issued.

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No definition available.

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- Definition

Number of shares of stock issued attributable to transactions classified as other.

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Value of shares of stock issued attributable to transactions classified as other.

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STOCKHOLDERS' EQUITY (Details Narrative 3) - USD ($)					3 Months Ended		9 Months Ended
STOCKHOLDERS' EQUITY (Details Narrative 3) - USD ($)	Sep. 28, 2017	Sep. 25, 2017	Aug. 06, 2017	Aug. 01, 2017	Sep. 30, 2018	Sep. 30, 2017	Sep. 30, 2018	Sep. 30, 2017	Dec. 31, 2017
Share-based compensation expense					$ 2,109,218	$ 1,885,050	$ 5,981,343	$ 4,691,735
Total unrecognized estimated compensation expense					$ 14,203,000		$ 14,203,000
Recognized weighted-average period							2 years 2 months 12 days
Underwriting Agreement [Member] \| Goldman Sachs & Co. LLC, [Member]
Issue of common stock (in shares)				12,745,098
Issue of common stock (in dollars per shares)				$ 5.10
Common stock exercisable shares				1,911,764
Stock exercisable period				30 days
Net Proceeds				$ 69,908,000
Underwriting Agreement [Member] \| J.P. Morgan Securities LLC [Member]
Issue of common stock (in shares)	12,400,000	12,400,000
Issue of common stock (in dollars per shares)		$ 5.55
Net Proceeds		$ 68,573,000
Knight License Agreement [Member] \| Knight Therapeutics Inc. [Member]
Issue of common stock value			$ 20,000,000
Stock Options [Member]
Options outstanding, ending					24,837,349		24,837,349		23,365,225
Weighted average grant date fair value per share of options granted							$ 3.27	$ 3.82
Options outstanding					$ 4.15		4.15		$ 3.78
Stock Options [Member] \| Minimum [Member]
Option exercise prices (in dollars per shares)					0.10		0.10
Stock Options [Member] \| Maximum [Member]
Option exercise prices (in dollars per shares)					$ 8.92		$ 8.92
Cash-Settled Stock Appreciation Rights (SARs) [Member]
Options outstanding, ending					106,000		106,000
Options outstanding					$ 1.36		$ 1.36
2012 Stock Incentive Plan [Member]
Number of shares authorized for issuance					10,000,000		10,000,000
Number of shares available for issuance					3,473,333		3,473,333
2009 Long Term Incentive Compensation Plan [Member]
Number of shares authorized for issuance					25,000,000		25,000,000
Number of shares available for issuance					900,037		900,037
Warrants [Member]
Recognized weighted-average period							6 months
Warrants [Member] \| Individuals [Member]
Shares issued for exercise of warrants, net								$ 3,798,999
Shares issued for exercise of warrants, net (in shares)								2,476,666