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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |
Net loss | $ (132,617,160) | $ (76,925,380) | $ (89,875,459)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation of fixed assets | 181,412 | 141,601 | 77,906
Amortization of intangible assets | 112,474 | 71,516 | 54,545
Provision for doubtful accounts | 216,022 | 4,206 | 2,524,909
Share-based compensation | 8,661,967 | 6,889,323 | 17,411,021
Amortization of deferred financing costs | 269,859 |  |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (6,951,041) | 167,691 | (3,975,893)
Inventory | (1,782,312) | (409,037) | (386,168)
Other current assets | (2,332,335) | (4,434,130) | 709,907
Other assets | (324,855) |  |
Accounts payable | 18,646,241 | (3,260,914) | 4,232,340
Accrued expenses and other current liabilities | 9,107,947 | 1,599,510 | 84,559
Net cash used in operating activities | (106,811,781) | (76,155,614) | (69,142,333)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Payment for intellectual property license | (20,000,000) |  |
Patent costs | (1,105,407) | (765,291) | (845,266)
Purchase of fixed assets | (217,040) | (61,817) | (396,154)
Payment of security deposit | (175,410) |  | (14,036)
Net cash used in investing activities | (21,497,857) | (827,108) | (1,255,456)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from sale of common stock, net of costs | 89,907,797 | 68,572,635 | 134,863,475
Proceeds from term loan | 75,000,000 |  |
Payment of deferred financing fees | (3,786,918) |  |
Proceeds from exercise of options | 1,666,208 | 212,615 | 989,060
Proceeds from exercise of warrants |  | 3,798,999 | 1,373,000
Net cash provided by financing activities | 162,787,087 | 72,584,249 | 137,225,535
Increase (decrease) in cash | 34,477,449 | (4,398,473) | 66,827,746
Cash, beginning of period | 127,135,628 | 131,534,101 | 64,706,355
Cash, end of period | 161,613,077 | $ 127,135,628 | $ 131,534,101
Supplemental disclosure of cash flow information |  |  |
Interest paid | $ 1,890,166 |  |

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