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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Common Stock | Additional Paid in Capital | Accumulated Deficit | Total
--- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2015 | $ 177,928 | $ 282,712,078 | $ (219,826,860) | $ 63,063,146
Beginning balance (in shares) at Dec. 31, 2015 | 177,928,041 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 17,424 | 134,846,051 |  | 134,863,475
Shares issued in offerings, net of cost (in shares) | 17,424,242 |  |  |
Shares issued for exercise of options, net | $ 723 | 1,372,277 |  | 1,373,000
Shares issued for exercise of options, net (in shares) | 722,744 |  |  |
Shares issued for exercise of warrants, net | $ 613 | 988,447 |  | 989,060
Shares issued for exercise of warrants, net (in shares) | 613,195 |  |  |
Share-based compensation |  | 17,076,199 |  | 17,076,199
Net loss |  |  | (89,875,459) | (89,875,459)
Ending balance at Dec. 31, 2016 | $ 196,688 | 436,995,052 | (309,702,319) | 127,489,421
Ending balance (in shares) at Dec. 31, 2016 | 196,688,222 |  |  |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 12,400 | 68,560,235 |  | 68,572,635
Shares issued in offerings, net of cost (in shares) | 12,400,000 |  |  |
Shares issued for exercise of options, net | $ 103 | 212,512 |  | 212,615
Shares issued for exercise of options, net (in shares) | 102,546 |  |  |
Shares issued for exercise of warrants, net | $ 7,239 | 3,791,760 |  | 3,798,999
Shares issued for exercise of warrants, net (in shares) | 7,238,874 |  |  |
Share-based compensation |  | 6,760,425 |  | 6,760,425
Adoption of ASU 2016-09 at Dec. 31, 2016 |  | 31,421 | (31,421) |
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |
Net loss |  |  | (76,925,380) | (76,925,380)
Ending balance at Dec. 31, 2017 | $ 216,430 | 516,351,405 | (386,659,120) | $ 129,908,715
Ending balance (in shares) at Dec. 31, 2017 | 216,429,642 |  |  | 216,429,642
Increase (Decrease) in Stockholders' Equity [Roll Forward] |  |  |  |
Shares issued in offerings, net of cost | $ 18,578 | 89,889,219 |  | $ 89,907,797
Shares issued in offerings, net of cost (in shares) | 18,578,430 |  |  |
Shares issued for exercise of options, net | $ 5,455 | 1,660,753 |  | 1,666,208
Shares issued for exercise of options, net (in shares) | 5,454,367 |  |  |
Share-based compensation |  | 8,658,561 |  | 8,658,561
Net loss |  |  | (132,617,160) | (132,617,160)
Ending balance at Dec. 31, 2018 | $ 240,463 | $ 616,559,938 | $ (519,276,280) | $ 97,524,121
Ending balance (in shares) at Dec. 31, 2018 | 240,462,439 |  |  | 240,462,439

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