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STOCKHOLDERS' EQUITY (Details Narrative) - USD ($) |  |  |  |  |  |  | 12 Months Ended
--- | --- | --- | --- | --- | --- | --- | ---
Aug. 06, 2018 | Sep. 28, 2017 | Sep. 25, 2017 | Aug. 01, 2017 | Jan. 12, 2016 | Jan. 06, 2016 | Dec. 31, 2018 | Dec. 31, 2017 | Dec. 31, 2016
Preferred stock, par value (in dollars per share) |  |  |  |  |  |  | $ 0.001 | $ 0.001 |
Preferred stock, authorized |  |  |  |  |  |  | 10,000,000 | 10,000,000 |
Common stock, authorized |  |  |  |  |  |  | 350,000,000 | 350,000,000 |
Common stock, issued |  |  |  |  |  |  | 240,462,439 | 216,429,642 |
Common stock, outstanding |  |  |  |  |  |  | 240,462,439 | 216,429,642 |
Value of common stock issued during period for stock options exercised |  |  |  |  |  |  | $ 1,666,208 | $ 212,615 | $ 1,373,000
Proceeds from sale of common stock, net of costs |  |  |  |  |  |  | 89,907,797 | 68,572,635 | 134,863,475
Underwriting Agreement [Member] | Goldman Sachs & Co. LLC, [Member] |  |  |  |  |  |  |  |  |
Issue of common stock (in shares) |  |  |  | 12,745,098 |  |  |  |  |
Issue of common stock (in dollars per shares) |  |  |  | $ 5.10 |  |  |  |  |
Common stock exercisable shares |  |  |  | 1,911,764 |  |  |  |  |
Stock exercisable period |  |  |  | 30 days |  |  |  |  |
Net Proceeds |  |  |  | $ 69,908,000 |  |  |  |  |
Underwriting Agreement [Member] | J.P. Morgan Securities LLC [Member] |  |  |  |  |  |  |  |  |
Issue of common stock (in shares) |  | 12,400,000 | 12,400,000 |  |  |  |  |  |
Issue of common stock (in dollars per shares) |  |  | $ 5.55 |  |  |  |  |  |
Net Proceeds |  |  | $ 68,573,000 |  |  |  |  |  |
Knight License Agreement [Member] | Knight Therapeutics Inc. [Member] |  |  |  |  |  |  |  |  |
Issue of common stock (in shares) | 3,921,568 |  |  |  |  |  |  |  |
Issue of common stock (in dollars per shares) | $ 5.10 |  |  |  |  |  |  |  |
Net Proceeds | $ 20,000,000 |  |  |  |  |  |  |  |
Underwriting Agreement - Goldman and Cowen [Member] |  |  |  |  |  |  |  |  |
Number of shares offered in underwriting agreement |  |  |  |  |  | 15,151,515 |  |  |
Share price (in dollars per share) |  |  |  |  |  | $ 8.25 |  |  |
Number of days of the option to purchase shares |  |  |  |  |  | 30 days |  |  |
Additional common stock issued under offering |  |  |  |  |  | 2,272,727 |  |  |
Proceeds from sale of common stock, net of costs |  |  |  |  |  | $ 134,864,000 |  |  |
Number of shares issued during the period |  |  |  |  | 17,424,242 |  |  |  |
Stock Options [Member] |  |  |  |  |  |  |  |  |
Value of common stock issued during period for stock options exercised |  |  |  |  |  |  | $ 1,666,208 | $ 212,615 | $ 989,060
Number of stock options exercised (in shares) |  |  |  |  |  |  | 5,444,526 | 102,546 | 525,362
Number of stock options exercised in cashless exercise (in shares) |  |  |  |  |  |  | 10,000 |  | 127,109
Number of common stock issued during period for stock options exercised in cashless exercise (in shares) |  |  |  |  |  |  | 9,841 |  | 87,833

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