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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY (Unaudited) - USD ($) | Common Stock [Member] | Additional Paid in Capital [Member] | Accumulated Deficit [Member] | Total
--- | --- | --- | --- | ---
Beginning balance at Dec. 31, 2017 | $ 216,430 | $ 516,351,405 | $ (386,659,120) | $ 129,908,715
Beginning balance (in shares) at Dec. 31, 2017 | 216,429,642 |  |  |
Shares issued for exercise of options, net | $ 154 | 43,902 |  | 44,056
Shares issued for exercise of options, net (in shares) | 154,632 |  |  |
Share-based compensation |  | 1,751,358 |  | 1,751,358
Net loss |  |  | (24,401,829) | (24,401,829)
Ending balance at Mar. 31, 2018 | $ 216,584 | 518,146,665 | (411,060,949) | 107,302,300
Ending balance (in shares) at Mar. 31, 2018 | 216,584,274 |  |  |
Beginning balance at Dec. 31, 2018 | $ 240,463 | 616,559,938 | (519,276,280) | $ 97,524,121
Beginning balance (in shares) at Dec. 31, 2018 | 240,462,439 |  |  | 240,462,439
Shares issued for exercise of options, net | $ 759 | 99,348 |  | $ 100,107
Shares issued for exercise of options, net (in shares) | 759,401 |  |  |
Share-based compensation |  | 2,575,369 |  | 2,575,369
Net loss |  |  | (39,506,375) | (39,506,375)
Ending balance at Mar. 31, 2019 | $ 241,222 | $ 619,234,655 | $ (558,782,655) | $ 60,693,222
Ending balance (in shares) at Mar. 31, 2019 | 241,221,840 |  |  | 241,221,840

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