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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' EQUITY - USD ($) | Common Stock [Member] | Additional Paid-in Capital [Member] | Retained Earnings [Member] | Total
--- | --- | --- | --- | ---
Beginning balance, value at Dec. 31, 2017 | $ 216,430 | $ 516,351,405 | $ (386,659,120) | $ 129,908,715
Common Stock, Shares, Outstanding, Beginning Balance at Dec. 31, 2017 | 216,429,642 |  |  |
Shares issued for exercise of options, net | $ 154 | 43,902 |  | 44,056
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period | 154,632 |  |  |
Share-based compensation |  | 1,751,358 |  | 1,751,358
Net loss |  |  | (24,401,829) | (24,401,829)
Common Stock, Shares, Outstanding, Ending Balance at Mar. 31, 2018 | 216,584,274 |  |  |
Ending balance, value at Mar. 31, 2018 | $ 216,584 | 518,146,665 | (411,060,949) | 107,302,300
Beginning balance, value at Dec. 31, 2017 | $ 216,430 | 516,351,405 | (386,659,120) | 129,908,715
Common Stock, Shares, Outstanding, Beginning Balance at Dec. 31, 2017 | 216,429,642 |  |  |
Shares issued for exercise of options, net |  |  |  | $ 1,236,313
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period |  |  |  | 1,446,876
Net loss |  |  |  | $ (93,226,179)
Common Stock, Shares, Outstanding, Ending Balance at Sep. 30, 2018 | 236,464,789 |  |  |
Ending balance, value at Sep. 30, 2018 | $ 236,465 | 613,864,115 | (479,885,299) | 134,215,281
Beginning balance, value at Mar. 31, 2018 | $ 216,584 | 518,146,665 | (411,060,949) | 107,302,300
Common Stock, Shares, Outstanding, Beginning Balance at Mar. 31, 2018 | 216,584,274 |  |  |
Shares issued for exercise of options, net | $ 250 | 1,084,689 |  | 1,084,939
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period | 249,785 |  |  |
Share-based compensation |  | 2,377,082 |  | 2,377,082
Net loss |  |  | (33,219,048) | (33,219,048)
Common Stock, Shares, Outstanding, Ending Balance at Jun. 30, 2018 | 216,834,059 |  |  |
Ending balance, value at Jun. 30, 2018 | $ 216,834 | 521,608,436 | (444,279,997) | 77,545,273
Shares issued for exercise of options, net | $ 1,053 | 106,265 |  | $ 107,318
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period | 1,052,300 |  |  | 1,052,300
Share-based compensation |  | 2,260,195 |  | $ 2,260,195
Net loss |  |  | (35,605,302) | (35,605,302)
Common Stock, Shares, Outstanding, Ending Balance at Sep. 30, 2018 | 236,464,789 |  |  |
Shares issued in offering, net | $ 18,578 | 89,889,219 |  | 89,907,797
Stock Issued During Period, Shares, New Issues | 18,578,430 |  |  |
Ending balance, value at Sep. 30, 2018 | $ 236,465 | 613,864,115 | (479,885,299) | 134,215,281
Beginning balance, value at Dec. 31, 2018 | $ 240,463 | 616,559,938 | (519,276,280) | $ 97,524,121
Common Stock, Shares, Outstanding, Beginning Balance at Dec. 31, 2018 | 240,462,439 |  |  | 240,462,439
Share-based compensation |  | 2,575,369 |  | $ 2,575,369
Net loss |  |  | (39,506,375) | (39,506,375)
Common Stock, Shares, Outstanding, Ending Balance at Mar. 31, 2019 | 241,221,840 |  |  |
Shares issued for exercise of options and warrants, net | $ 759 | 99,348 |  | 100,107
Stock Issued During Period, Shares, Other | 759,401 |  |  |
Ending balance, value at Mar. 31, 2019 | $ 241,222 | 619,234,655 | (558,782,655) | 60,693,222
Beginning balance, value at Dec. 31, 2018 | $ 240,463 | 616,559,938 | (519,276,280) | $ 97,524,121
Common Stock, Shares, Outstanding, Beginning Balance at Dec. 31, 2018 | 240,462,439 |  |  | 240,462,439
Shares issued for exercise of options, net |  |  |  | $ 108,656
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period |  |  |  | 331,619
Net loss |  |  |  | $ (126,709,485)
Common Stock, Shares, Outstanding, Ending Balance at Sep. 30, 2019 | 241,277,076 |  |  | 241,277,076
Ending balance, value at Sep. 30, 2019 | $ 241,277 | 624,515,559 | (645,985,765) | $ (21,228,929)
Beginning balance, value at Mar. 31, 2019 | $ 241,222 | 619,234,655 | (558,782,655) | 60,693,222
Common Stock, Shares, Outstanding, Beginning Balance at Mar. 31, 2019 | 241,221,840 |  |  |
Share-based compensation |  | 2,637,264 |  | 2,637,264
Net loss |  |  | (55,236,517) | (55,236,517)
Common Stock, Shares, Outstanding, Ending Balance at Jun. 30, 2019 | 241,221,840 |  |  |
Ending balance, value at Jun. 30, 2019 | $ 241,222 | 621,871,919 | (614,019,172) | 8,093,969
Shares issued for exercise of options, net | $ 55 | 8,494 |  | $ 8,549
Share-based Compensation Arrangement by Share-based Payment Award, Options, Exercises in Period | 55,236 |  |  | 55,236
Share-based compensation |  | 2,635,146 |  | $ 2,635,146
Net loss |  |  | (31,966,593) | $ (31,966,593)
Common Stock, Shares, Outstanding, Ending Balance at Sep. 30, 2019 | 241,277,076 |  |  | 241,277,076
Ending balance, value at Sep. 30, 2019 | $ 241,277 | $ 624,515,559 | $ (645,985,765) | $ (21,228,929)

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