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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018 | Dec. 31, 2017
CASH FLOWS FROM OPERATING ACTIVITIES |  |  |
Net loss | $ (176,144,999) | $ (132,617,160) | $ (76,925,380)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation of fixed assets | 415,193 | 181,412 | 141,601
Amortization of intangible assets | 197,593 | 112,474 | 71,516
Write off of patent and trademark cost | 78,864 |  |
Non-cash operating lease expense | 1,062,318 |  |
Provision for doubtful accounts | 307,438 | 216,022 | 4,206
Loss of extinguishment of debt | 10,057,632 |  |
Share-based compensation | 10,693,662 | 8,661,967 | 6,889,323
Amortization of intellectual property license fee | 778,692 |  |
Amortization of deferred financing costs | 856,302 | 269,859 |
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (13,639,575) | (6,951,041) | 167,691
Inventory | (8,593,046) | (1,782,312) | (409,037)
Other assets | (1,880,048) | (2,657,190) | (4,434,130)
Accounts payable | (3,562,629) | 18,646,241 | (3,260,914)
Accrued expenses and other liabilities | 13,675,008 | 9,107,947 | 1,599,510
Net cash used in operating activities | (165,697,595) | (106,811,781) | (76,155,614)
CASH FLOWS FROM INVESTING ACTIVITIES |  |  |
Payment for intellectual property license | (20,000,000) | (20,000,000) |
Patent costs | (1,441,989) | (1,105,407) | (765,291)
Purchase of fixed assets | (2,450,285) | (217,040) | (61,817)
Payment of security deposit | (20,420) | (175,410) |
Net cash used in investing activities | (23,912,694) | (21,497,857) | (827,108)
CASH FLOWS FROM FINANCING ACTIVITIES |  |  |
Proceeds from exercise of options and warrants | 108,656 | 1,666,208 | 4,011,614
Proceeds from sale of common stock, net of costs | 77,031,258 | 89,907,797 | 68,572,635
Proceeds from Financing Agreement | 200,000,000 |  |
Proceeds from Credit Agreement |  | 75,000,000 |
Payment of deferred financing fees | (6,652,270) | (3,786,918) |
Repayment of Credit Agreement | (81,660,719) |  |
Net cash provided by financing activities | 188,826,925 | 162,787,087 | 72,584,249
(Decrease) increase in cash | (783,364) | 34,477,449 | (4,398,473)
Cash, beginning of period | 161,613,077 | 127,135,628 | 131,534,101
Cash, end of period | 160,829,713 | 161,613,077 | 127,135,628
Supplemental disclosure of cash flow information |  |  |
Interest paid | $ 17,787,903 | $ 1,890,166 |

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- Definition Amount of cash inflow from contractual arrangement with the lender, including but not limited to, letter of credit, standby letter of credit and revolving credit arrangements. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3255-108585 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 1 -Subparagraph (SX 210.4-08.(f)) -URI http://asc.fasb.org/extlink&oid=26873400&loc=d3e23780-122690 + Details
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- Definition Amount of expense (reversal of expense) for expected credit loss on accounts receivable. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 326 -SubTopic 20 -Section 50 -Paragraph 13 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=119407570&loc=SL82919249-210447 Reference 2: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 220 -SubTopic 10 -Section S99 -Paragraph 2 -Subparagraph (SX 210.5-03(5)) -URI http://asc.fasb.org/extlink&oid=116634182&loc=SL114868664-224227 + Details
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- Definition Amount of cash outflow for the payment of debt classified as other, maturing after one year or the operating cycle, if longer. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=118932676&loc=d3e3291-108585 + Details
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