<SEC-DOCUMENT>0001387131-20-004411.txt : 20200504
<SEC-HEADER>0001387131-20-004411.hdr.sgml : 20200504
<ACCEPTANCE-DATETIME>20200504170329
ACCESSION NUMBER:		0001387131-20-004411
CONFORMED SUBMISSION TYPE:	DEFA14A
PUBLIC DOCUMENT COUNT:		3
FILED AS OF DATE:		20200504
DATE AS OF CHANGE:		20200504
EFFECTIVENESS DATE:		20200504

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TherapeuticsMD, Inc.
		CENTRAL INDEX KEY:			0000025743
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		IRS NUMBER:				870233535
		STATE OF INCORPORATION:			NV
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		DEFA14A
		SEC ACT:		1934 Act
		SEC FILE NUMBER:	001-00100
		FILM NUMBER:		20845729

	BUSINESS ADDRESS:	
		STREET 1:		951 YAMATO ROAD, SUITE 220
		CITY:			BOCA RATON
		STATE:			FL
		ZIP:			33431
		BUSINESS PHONE:		561-961-1900

	MAIL ADDRESS:	
		STREET 1:		951 YAMATO ROAD, SUITE 220
		CITY:			BOCA RATON
		STATE:			FL
		ZIP:			33431

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	AMHN, Inc.
		DATE OF NAME CHANGE:	20090930

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CROFF ENTERPRISES INC
		DATE OF NAME CHANGE:	19970915

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	CROFF OIL CO
		DATE OF NAME CHANGE:	19920703
</SEC-HEADER>
<DOCUMENT>
<TYPE>DEFA14A
<SEQUENCE>1
<FILENAME>txmd-defa14a_061820.htm
<DESCRIPTION>ADDITIONAL DEFINITIVE PROXY SOLICITING MATERIALS
<TEXT>
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<head>
     <title></title>
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<body style="font: 10pt Times New Roman, Times, Serif">
<!-- Field: Rule-Page --><DIV STYLE="margin-top: 0pt; margin-bottom: 3pt; width: 100%"><DIV STYLE="font-size: 1pt; border-top: Black 2pt solid; border-bottom: Black 1pt solid">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->

<P STYLE="font: 1pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>UNITED STATES</B></P>

<P STYLE="font: 14pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>SECURITIES AND EXCHANGE
COMMISSION</B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>Washington, DC 20549</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white">&nbsp;</P>

<P STYLE="font: 13.5pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>SCHEDULE 14A</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white">&nbsp;</P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>Proxy Statement Pursuant
to Section 14(a) of the</B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>Securities Exchange
Act of 1934</B></P>

<P STYLE="font: 9pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>(Amendment No.&nbsp;&nbsp;
)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">Filed by the Registrant&nbsp;&nbsp;<FONT STYLE="font-family: Segoe UI Symbol,sans-serif">&#9746;</FONT>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">Filed by a party other than the Registrant&nbsp;&nbsp;<FONT STYLE="font-family: Segoe UI Symbol,sans-serif">&#9744;</FONT></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">Check the appropriate box:</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
<TR>
    <TD STYLE="width: 1%">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom; width: 1%">&nbsp;</TD>
    <TD STYLE="width: 98%">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top">&#9744;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Preliminary Proxy Statement</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt"><B>Confidential, for Use of the Commission Only (as permitted by Rule 14a-6(e)(2))</B></FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Definitive Proxy Statement</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9746;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Definitive Additional Materials</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 10pt">Soliciting Material Pursuant to &sect;240.14a-12</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>&nbsp;</B></P>

<P STYLE="font: 18pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>TherapeuticsMD,
Inc.</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>(Name of Registrant
as Specified in its Charter)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white"><B>(Name of Person(s)
Filing Proxy Statement, if other than the Registrant)</B></P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; text-align: center; background-color: white">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0; background-color: white">Payment of Filing Fee (Check the appropriate
box):</P>

<TABLE CELLSPACING="0" CELLPADDING="0" STYLE="font: 12pt Times New Roman, Times, Serif; width: 100%; background-color: white; border-collapse: collapse">
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9746;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">No fee required.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Fee computed on table below per Exchange Act Rules 14a-6(i)(1) and 0-11.</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">1)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Title of each class of securities to which transaction applies:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">2)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Aggregate number of securities to which transaction applies:&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">3)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Per unit price or other underlying value of transaction computed pursuant to Exchange Act Rule 0-11 (set forth the amount on which the filing fee is calculated and state how it was determined):&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">4)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Proposed maximum aggregate value of transaction:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">5)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Total fee paid:&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="4">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Fee paid previously with preliminary materials.</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-family: Segoe UI Symbol,sans-serif; font-size: 10pt">&#9744;</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD COLSPAN="3" STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Check box if any part of the fee is offset as provided by Exchange Act Rule 0-11(a)(2) and identify the filing for which the offsetting fee was paid previously. Identify the previous filing by registration statement number, or the Form or Schedule and the date of its filing.</FONT></TD></TR>
<TR>
    <TD>&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD>
    <TD COLSPAN="2">&nbsp;</TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">1)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Amount previously paid:</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">2)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Form, Schedule or Registration Statement No.:&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">3)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Filing party:&nbsp;</FONT></TD></TR>
<TR>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">4)</FONT></TD>
    <TD STYLE="vertical-align: bottom">&nbsp;</TD>
    <TD STYLE="vertical-align: top"><FONT STYLE="font-size: 10pt">Date Filed:&nbsp;</FONT></TD></TR>
</TABLE>
<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0">&nbsp;</P>

<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"></P>

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<P STYLE="font: 10pt Times New Roman, Times, Serif; margin: 0"><B></B></p>

<p style="font: 17pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>

<p style="font: 17pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"></p>

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    <DIV STYLE="page-break-before: always; margin-top: 6pt"><TABLE CELLPADDING="0" CELLSPACING="0" STYLE="width: 100%"><TR><TD STYLE="text-align: center; width: 100%">&nbsp;</TD></TR></TABLE></DIV>
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<p style="font: 17pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><FONT STYLE="font-family: Times New Roman, Times, Serif"><B></b></font></p>

<p style="font: 17pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif"><b>&nbsp;</b></font></p>

<p style="font: 17pt Times New Roman, Times, Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: center"><font style="font-family: Times New Roman, Times, Serif"><b>***
 Exercise Your <I>Right</I> to Vote ***</B></FONT><B> </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center"><B>Important Notice Regarding the Availability of Proxy Materials for the </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center"><B>Stockholder Meeting to Be Held on June 18, 2020. </B></P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P><DIV><DIV STYLE="position:relative;float:left; width:48%;padding-right:0%;padding-bottom:8pt;overflow:hidden;padding-top:3pt">
 <P STYLE="margin-top:12pt; margin-bottom:0pt; font-size:12pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center"><B></B><B><I></I></B><B>THERAPEUTICSMD, INC.</B><B><I></I></B><B> </B></P>
<P STYLE="font-size:36pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:36pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top: 0pt; margin-bottom: 0pt; text-align: left; margin-left: 0.25in"> <IMG SRC="txmd-def14a001.jpg" ALT="LOGO">
 </P> <P STYLE="font-size:24pt;margin-top:0pt;margin-bottom:0pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 7pt">&nbsp;</FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt; margin-left: 0.25in"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 7pt"><I>THERAPEUTICSMD, INC. <BR>
951 YAMATO ROAD, SUITE 220<BR>
BOCA RATON, FL 33431</I></FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font: 7pt  Arial, Helvetica, Sans-Serif"><I>&nbsp;</I></FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font: 7pt  Arial, Helvetica, Sans-Serif"><I>&nbsp;</I></FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font: 7pt  Arial, Helvetica, Sans-Serif"><I>&nbsp;</I></FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font: 7pt  Arial, Helvetica, Sans-Serif"><I>&nbsp;</I></FONT></P>

<P STYLE="font-size: 24pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font: 7pt  Arial, Helvetica, Sans-Serif"><I>&nbsp;</I></FONT></P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="justify">



 </P></DIV></DIV><DIV><DIV STYLE="position:relative;float:left; margin-left:3%; width:49%;padding-right:0%;padding-bottom:8pt;overflow:hidden;padding-top:3pt">
 <div style="max-width:100%;margin-left:0%; margin-right:0%;border:solid 1pt; padding-top:2pt;padding-bottom:3pt">
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="98%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt" ALIGN="center">


<TR>
<TD WIDTH="32%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="67%"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top" COLSPAN="3" ALIGN="center"><FONT STYLE="font-size:11pt"><B><U>Meeting Information</U></B></FONT></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:1pt; margin-bottom:1pt; font-size:9pt; font-family:Arial, Helvetica, Sans-Serif"><B>Meeting Type:&nbsp;&nbsp;
</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;Annual Meeting <B></B></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top" COLSPAN="3"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:1pt; margin-bottom:1pt; font-size:9pt; font-family:Arial, Helvetica, Sans-Serif"><B>For holders as of:&nbsp;&nbsp;</B>April 20, 2020<B></B></P></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:1pt; margin-bottom:1pt; font-size:9pt; font-family:Arial, Helvetica, Sans-Serif"><B>Date:</B>&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;June 18, 2020</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P> <P STYLE="margin-top:1pt; margin-bottom:0pt; font-size:9pt; font-family:Arial, Helvetica, Sans-Serif"><B>&nbsp;&nbsp;&nbsp;&nbsp;Time:</B><B></B> &nbsp;&nbsp;&nbsp;&nbsp;8:00 a.m., Local Time</P> <P STYLE="font-size:6pt; margin-top:0pt; margin-bottom:1pt">&nbsp;</P></TD></TR></TABLE>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="98%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="18%"></TD>
<TD VALIGN="bottom" WIDTH="1%"></TD>
<TD WIDTH="81%"></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top"><FONT STYLE="font-size:10pt"><B>Location*:&nbsp;</B></FONT></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">Renaissance Boca Raton Hotel</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"><P STYLE="margin: 0">2000 NW 19th Street<BR>
Boca Raton, Florida 33431</P>


</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom"><FONT STYLE="font-size: 1pt">&nbsp;</FONT></TD>
<TD VALIGN="bottom"></TD></TR>                              <TR STYLE="page-break-inside: avoid; font: 9pt Arial, Helvetica, Sans-Serif">
<TD COLSPAN="3" STYLE="vertical-align: top"><P STYLE="text-align: justify; font: 7.5pt Arial, Helvetica, Sans-Serif; margin: 0"></P>


</TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt"></P></div> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Arial, Helvetica, Sans-Serif; font-size:9.5pt" ALIGN="center">


<TR>
<TD WIDTH="100%" STYLE="text-align: justify"></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9.5pt">
<TD VALIGN="TOP" STYLE="text-align: justify"><P STYLE="text-align: justify; margin-top: 0pt; margin-bottom: 0pt; font: 9.5pt Arial, Helvetica, Sans-Serif"></P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" STYLE="text-align: justify"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9.5pt">
<TD VALIGN="TOP" STYLE="text-align: justify"><P STYLE="text-align: justify; margin-top: 0pt; margin-bottom: 0pt; font: 9.5pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">*As
                  part of our precautions regarding the COVID-19 pandemic, we are planning for the possibility that the meeting
                  may be held only through remote communication. If a decision is made to forego the physical meeting, a news
                  release will be issued and the information with respect to the logistical details of the meeting, including
                  how stockholders can remotely access, participate in and vote at the meeting, will be posted on our website,
                  www.therapeuticsmd.com, and such information will be filed with the U.S. Securities and Exchange Commission
                  as proxy material, no later than June 8, 2020.</FONT></P></TD></TR>
<TR STYLE="font-size:1pt">
<TD HEIGHT="8" STYLE="text-align: justify"></TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:9.5pt">
<TD VALIGN="TOP" STYLE="text-align: justify"><P STYLE="text-align: justify; margin-top: 0pt; margin-bottom: 0pt; font: 9.5pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">You
                  are receiving this communication because you hold shares in the company named above.</FONT></P></TD></TR>                                                                                                                                <TR STYLE="page-break-inside: avoid; font: 9.5pt  Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 9.5pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">This is not a ballot. You cannot use this notice to vote these shares.
This communication presents only an overview of the more complete proxy materials that are available to you on the Internet. You
may view the proxy materials online at <I>www.proxyvote.com</I> or easily request a paper copy (see reverse side).</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 9.5pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 9.5pt  Arial, Helvetica, Sans-Serif">
<TD STYLE="text-align: justify; vertical-align: top"><FONT STYLE="font-size: 8pt">We encourage you to access and review all of
the important information contained in the proxy materials before voting.</FONT></TD></TR>
</TABLE> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt"><FONT STYLE="font-size: 5pt">&nbsp;</FONT></P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt" ALIGN="center">


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<TD VALIGN="bottom" WIDTH="1%"></TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:11pt">
<TD VALIGN="top" BGCOLOR="#000000"></TD>
<TD VALIGN="bottom" BGCOLOR="#000000">&nbsp;</TD>
<TD VALIGN="top" BGCOLOR="#000000"> <P ALIGN="justify" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Arial, Helvetica, Sans-Serif; font-size:11pt"><FONT COLOR="#FFFFFF"><B>See the reverse side of this notice to obtain proxy materials and voting instructions.</B></FONT></P></TD>
<TD VALIGN="bottom" BGCOLOR="#000000">&nbsp;</TD>
<TD VALIGN="top" BGCOLOR="#000000"></TD></TR>
</TABLE> </div></DIV><div style="clear:both; height:0pt; font-size:1pt">&nbsp;</div>
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 <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman, Times, Serif" ALIGN="center"><B>&#151; Before You Vote &#151; </B></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center">How to Access the Proxy Materials </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="font-size:2pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<Center><div style="width:98%;margin-left:2%; margin-right:0%;border:solid 1pt; padding-top:2pt;padding-bottom:3pt">
<P STYLE="margin: 0pt 2%; padding-top: 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: left"><B>Proxy Materials Available to VIEW or RECEIVE:</B> </P>
<P STYLE="margin: 6pt 2% 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: left">NOTICE AND PROXY STATEMENT&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp; 2019 ANNUAL REPORT </P>
<P STYLE="font-size: 6pt; margin: 0pt 2%; text-align: left">&nbsp;</P> <P STYLE="margin: 1pt 2% 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: left"><B>How to View Online:</B> </P>
<P STYLE="margin: 0pt 2%; font: 10pt Arial, Helvetica, Sans-Serif; text-align: justify">Have the information that is printed in the box marked by the arrow <IMG SRC="txmd-def14a002.jpg" ALT="LOGO">
 (located on the following page) and visit: <I>www.proxyvote.com.</I> </P> <P STYLE="font-size: 6pt; margin: 0pt 2%; text-align: left">&nbsp;</P>
<P STYLE="margin: 1pt 2% 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: left"><B>How to Request and Receive a PAPER or E-MAIL Copy:</B> </P>
<P STYLE="margin: 0pt 2%; font: 10pt Arial, Helvetica, Sans-Serif; text-align: justify">If you want to receive a paper or e-mail copy of these documents, you must request one. There is NO charge for requesting
a copy. Please choose one of the following methods to make your request:</P>
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<TD STYLE="width: 60%"></TD></TR>

<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">1) <I>BY INTERNET</I>:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">www.proxyvote.com</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">2)&nbsp;<I>BY&nbsp;TELEPHONE</I>:&nbsp;&nbsp;&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">1-800-579-1639</TD></TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt">
<TD VALIGN="top"></TD>
<TD VALIGN="bottom">&nbsp;&nbsp;</TD>
<TD VALIGN="bottom">3) <I>BY E-MAIL</I>*:</TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom">sendmaterial@proxyvote.com</TD></TR></TABLE>

<P STYLE="margin: 10pt 2% 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: justify">* If requesting materials by e-mail, please send a blank e-mail with the information that is printed in the box marked by the arrow


<IMG SRC="txmd-def14a002.jpg" ALT="LOGO">
 (located on the following page) in the subject line. </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin: 1pt 2% 0pt; padding-bottom: 0pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: justify">Requests, instructions and other inquiries sent to this e-mail address will NOT be forwarded to your investment advisor. Please
make the request as instructed above on or before June 4, 2020 to facilitate timely delivery. </P></div></Center>
<P STYLE="margin-top:18pt; margin-bottom:0pt; font-size:18pt; font-family:Times New Roman, Times, Serif" ALIGN="center"><B>&#151; How To
Vote &#151; </B></P> <P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:12pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center">Please Choose One of the Following Voting Methods </P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<TABLE CELLSPACING="0" CELLPADDING="0" WIDTH="100%" BORDER="0" STYLE="BORDER-COLLAPSE:COLLAPSE; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt" ALIGN="center">


<TR>
<TD WIDTH="2%"></TD>
<TD VALIGN="bottom" WIDTH="2%"></TD>
<TD STYLE="width: 96%; padding-right: 10pt"></TD></TR>


<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt">
<TD STYLE="vertical-align: middle; text-align: left; padding-top: 6pt; padding-bottom: 6pt">



</TD>
<TD STYLE="vertical-align: bottom; border-left: #000000 1pt solid; border-top: #000000 1pt solid; border-bottom: #000000 1pt solid; padding-top: 6pt; padding-bottom: 6pt">&nbsp;&nbsp;</TD>
<TD STYLE="vertical-align: top; border-top: #000000 1pt solid; border-right: #000000 1pt solid; border-bottom: #000000 1pt solid; padding-right: 10pt; padding-top: 6pt; padding-bottom: 6pt"> <P STYLE="font-size: 10pt; margin-top: 0pt; margin-bottom: 0pt; text-align: justify"><B>Vote
                                         In Person:</B> Many stockholder meetings have attendance requirements including, but
                                         not limited to, the possession of an attendance ticket issued by the entity holding the
                                         meeting. Please check the meeting materials for any special requirements for meeting
                                         attendance. At the meeting, you will need to request a ballot to vote these shares.</P> <P STYLE="font-size:3pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:10pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="justify"><B>Vote
By Internet: </B>To vote now by Internet, go to <I>www.proxyvote.com</I>. Have the information that is printed in the box marked
by the arrow <IMG SRC="txmd-def14a002.jpg" ALT="LOGO"> (located on the following page) available and follow the instructions.</P> <P STYLE="margin-top: 6pt; font: 10pt Arial, Helvetica, Sans-Serif; text-align: justify"><B>Vote
By Mail: </B>You can vote by mail by requesting a paper copy of the materials, which will include a proxy card.</P></TD></TR>
</TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>

<P STYLE="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 8pt">D08156-P38133</FONT></P>




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<TD VALIGN="top" COLSPAN="3" STYLE="BORDER:1.50pt solid #000000; padding-left:8pt"> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:0pt">&nbsp;</P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:8pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="center"><B>Voting Items</B></P> <P STYLE="font-size:1pt; margin-top:0pt; margin-bottom:1pt" align="left">&nbsp;</P></TD>
<TD VALIGN="bottom">&nbsp;</TD>
<TD VALIGN="bottom"></TD></TR></TABLE> <P STYLE="font-size:4pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
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<TD STYLE="width: 4%"></TD>
<TD STYLE="vertical-align: bottom; width: 1%"></TD>
<TD STYLE="width: 20%"></TD>
<TD STYLE="vertical-align: bottom; width: 1%"></TD>
<TD STYLE="width: 74%"></TD>
</TR>

<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:10pt">
<TD VALIGN="top" COLSPAN="3"><P ALIGN="justify" STYLE=" margin-top:0pt ; margin-bottom:0pt; font-family:Arial, Helvetica, Sans-Serif; font-size:7pt"><FONT STYLE="font-size: 8pt"><B>The
                              Board of Directors recommends you vote FOR the following:</B></FONT></P></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;&nbsp;</FONT></TD>
</TR>
<TR STYLE="font-size:1pt">
<TD STYLE="height: 8px"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
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<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:7pt">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">1.</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><P STYLE="margin-top:0pt; margin-bottom:0pt; font-size:7pt; font-family:Arial, Helvetica, Sans-Serif" ALIGN="justify"><FONT STYLE="font-size: 8pt">Election
                                 of Directors</FONT></P>
                  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 7pt Arial, Helvetica, Sans-Serif; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
                  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 7pt Arial, Helvetica, Sans-Serif; text-align: justify"><FONT STYLE="font-size: 8pt"><B>Nominees:</B></FONT></P>
                  <P STYLE="margin-top: 0pt; margin-bottom: 0pt; font: 7pt Arial, Helvetica, Sans-Serif; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:0pt; margin-left:1.00em; text-indent:-1.00em; font-size:7pt; font-family:Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">01)
&nbsp;&nbsp;Paul M. Bisaro</FONT></P>
<P STYLE="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font: 7pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">02)
&nbsp;&nbsp;J. Martin Carroll</FONT></P>
<P STYLE="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font: 7pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">03)
&nbsp;&nbsp;Cooper C. Collins</FONT></P>
<P STYLE="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font: 7pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">04)
&nbsp;&nbsp;Robert G. Finizio</FONT></P>
<P STYLE="margin-top: 0pt; margin-bottom: 0pt; margin-left: 1em; text-indent: -1em; font: 7pt Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">05)
&nbsp;&nbsp;Karen L. Ling&nbsp;</FONT></P>
<P STYLE="margin-top:0pt; margin-bottom:1pt; margin-left:1.00em; text-indent:-1.00em; font-size:7pt; font-family:Arial, Helvetica, Sans-Serif"></P></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">06) &nbsp;&nbsp;Jules A. Musing</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">07) &nbsp;&nbsp;Gail K. Naughton, Ph.D.</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">08) &nbsp;&nbsp;Angus C. Russell</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"><FONT STYLE="font-size: 8pt">09) &nbsp;&nbsp;Tommy G. Thompson</FONT></P>
                                <P STYLE="margin-top: 0; margin-bottom: 0"></P></TD>
</TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
</TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
</TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:7pt">
<TD VALIGN="TOP" COLSPAN="5"><P STYLE="text-align: justify; font: 7pt  Arial, Helvetica, Sans-Serif; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-size: 8pt"><B>The
                             Board of Directors recommends you vote FOR the following proposal:</B></FONT></P>

 </TD>
</TR>
<TR STYLE="font-size:1pt">
<TD STYLE="height: 8px"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
</TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:7pt">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">2.</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><P STYLE="font: 7pt Arial, Helvetica, Sans-Serif; margin-top: 0pt; margin-bottom: 0pt; text-align: justify"><FONT STYLE="font-size: 8pt">To
                                         approve, on a non-binding advisory basis, the compensation of our named executive officers
                                         for the fiscal year ended December 31, 2019 (say-on-pay);</FONT></P>

 </TD>
</TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD COLSPAN="5" STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt"><B>The Board of Directors recommends you vote FOR the
following proposal:</B></FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">3.</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">To approve an amendment to the
Amended and Restated Articles of Incorporation, as amended, to increase the number of authorized shares of common stock,
$0.001 par value per share, from 350,000,000 shares to 600,000,000 shares;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD COLSPAN="5" STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt"><B>The Board of Directors recommends you vote FOR the
following proposal:</B></FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">4.</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">To approve the TherapeuticsMD,
Inc. 2020 Employee Stock Purchase Plan;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD COLSPAN="5" STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt"><B>The Board of Directors recommends you vote FOR the
following proposal:</B></FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD></TR>
<TR STYLE="page-break-inside: avoid; font: 7pt Arial, Helvetica, Sans-Serif">
<TD STYLE="vertical-align: top"><FONT STYLE="font-size: 8pt">5.</FONT></TD>
<TD STYLE="vertical-align: bottom"><FONT STYLE="font-size: 8pt">&nbsp;</FONT></TD>
<TD COLSPAN="3" STYLE="vertical-align: top; text-align: justify"><FONT STYLE="font-size: 8pt">To ratify the appointment of Grant Thornton LLP, an independent
registered public accounting firm, as the independent auditor of our company for the fiscal year ending December 31, 2020;</FONT></TD></TR>
<TR STYLE="font-size:1pt">
<TD STYLE="height: 8px"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
</TR>
<TR STYLE="page-break-inside:avoid ; font-family:Arial, Helvetica, Sans-Serif; font-size:7pt">
<TD COLSPAN="5" STYLE="vertical-align: top"><P STYLE="text-align: justify; margin-top: 0pt; margin-bottom: 0pt; font: 7pt  Arial, Helvetica, Sans-Serif"><FONT STYLE="font-size: 8pt">and
                                         upon such other business as may properly come before the meeting or any adjournment thereof.</FONT></P>

</TD>
</TR>
<TR STYLE="font-size:1pt">
<TD STYLE="height: 8px"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
<TD HEIGHT="8" COLSPAN="2"></TD>
</TR>
</TABLE> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:6pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 8pt">D08157-P38133</FONT></P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="justify"></P>






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<P STYLE="font-size:36pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:36pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:36pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>
<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P> <P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>

<!-- Field: Rule-Page --><DIV ALIGN="LEFT" STYLE="margin-top: 3pt; margin-bottom: 3pt"><DIV STYLE="font-size: 1pt; border-top: Black 4pt solid; border-bottom: Black 1pt solid; width: 100%">&nbsp;</DIV></DIV><!-- Field: /Rule-Page -->


<P STYLE="font-size:12pt;margin-top:0pt;margin-bottom:0pt">&nbsp;</P>

<P STYLE="font-size: 12pt; margin-top: 0pt; margin-bottom: 0pt"><FONT STYLE="font-family: Arial, Helvetica, Sans-Serif; font-size: 8pt">D08158-P38133</FONT></P> <P STYLE="margin-top:0pt;margin-bottom:0pt" ALIGN="justify"></P>



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