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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' (DEFICIT) EQUITY - USD ($)
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2017 $ 216,430 $ 516,351,405 $ (386,659,120) $ 129,908,715
Balance at beginning (in shares) at Dec. 31, 2017 216,429,642      
Shares issued in offerings, net of cost $ 18,578 89,889,219 89,907,797
Shares issued in offerings, net of cost (in shares) 18,578,430      
Shares issued for exercise of options and warrants, net $ 5,455 1,660,753 1,666,208
Shares issued for exercise of options and warrants, net (in shares) 5,454,367      
Share-based compensation 8,658,561 8,658,561
Net loss (132,617,160) (132,617,160)
Ending balance, value at Dec. 31, 2018 $ 240,463 616,559,938 (519,276,280) 97,524,121
Balance at ending (in shares) at Dec. 31, 2018 240,462,439      
Shares issued in offerings, net of cost $ 29,900 77,001,358 77,031,258
Shares issued in offerings, net of cost (in shares) 29,900,000      
Shares issued for exercise of options and warrants, net $ 814 107,842 108,656
Shares issued for exercise of options and warrants, net (in shares) 814,637      
Share-based compensation 10,682,084 10,682,084
Net loss (176,144,999) (176,144,999)
Ending balance, value at Dec. 31, 2019 $ 271,177 704,351,222 (695,421,279) $ 9,201,120
Balance at ending (in shares) at Dec. 31, 2019 271,177,076     271,177,076
Shares issued in offerings, net of cost $ 26,953 31,675,682 $ 31,702,635
Shares issued in offerings, net of cost (in shares) 26,953,125      
Shares issued for exercise of options and warrants, net $ 1,182 270,496 271,678
Shares issued for exercise of options and warrants, net (in shares) 1,182,195      
Issuance of shares from release of restricted stock (in shares) 453,000      
Issuance of shares from release of restricted stock $ 453 (453)
Warrant granted in relation to Financing Agreement 7,668,161 7,668,161
Share-based compensation 10,678,992 10,678,992
Net loss (183,524,137) (183,524,137)
Ending balance, value at Dec. 31, 2020 $ 299,765 $ 754,644,100 $ (878,945,416) $ (124,001,551)
Balance at ending (in shares) at Dec. 31, 2020 299,765,396     299,765,396