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Summary quarterly information (unaudited) - Summary of Quarterly Information (Parenthetical) (Details) - USD ($) $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 | Sep. 30, 2021 | Jun. 30, 2021 | Mar. 31, 2021 | Dec. 31, 2020 | Sep. 30, 2020 | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenue, net | $ 18,678 | [1] | $ 25,406 | [2] | $ 23,001 | $ 19,866 | $ 22,578 | [3] | $ 19,342 | [4] | $ 10,701 | $ 12,251 | $ 86,951 | $ 64,872 | $ 49,647
Inventory charge |  |  |  |  |  |  |  |  | 5,700 |  |  |  |  |  |
Write-off of patent and trademark |  |  |  |  |  |  | $ 500 |  | 600 |  |  |  | $ 0 | $ 1,132 | $ 79
Knight License Agreement [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenue, net |  |  |  |  |  |  |  |  | $ 2,000 |  |  |  |  |  |
Senior Executive [Member] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Collaborative Arrangements And Noncollaborative Arrangement Transactions [Line Items] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Amount in severances | $ 5,100 |  | $ 7,300 |  |  |  |  |  |  |  |  |  |  |  |
[1] | Included $5.1 million in senior executive severances, which included our former CEO.
[2] | Included $7.3 million in senior executive severances, which included our former EVP of Operations.
[3] | Included $0.5 million in write off of certain costs related to trademarks and patents.
[4] | Included (i) $2.0 million in license revenue related to the Knight License Agreement, (ii) $5.7 million in inventory charge, primarily related to BIJUVA, and (iii) $0.6 million in write off of certain costs related to trademarks and patents.

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