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CONSOLIDATED STATEMENTS OF STOCKHOLDERS' (DEFICIT) - USD ($) $ in Thousands | Total | Common Stock [Member] | Additional Paid-in Capital [Member] | Accumulated Deficit [Member]
--- | --- | --- | --- | ---
Beginning balance, value at Dec. 31, 2018 | $ 97,524 | $ 240 | $ 616,560 | $ (519,276)
Beginning balance, shares at Dec. 31, 2018 |  | 240,462,000 |  |
Shares issued for sale of common stock, net of cost | 77,031 | $ 30 | 77,001 |
Shares issued for sale of common stock, net of cost (in shares) |  | 29,900,000 |  |
Shares issued for exercise of warrants, net of cashless exercises |  | $ 1 | (1) |
Shares issued for exercise of warrants, net of cashless exercises (in shares) |  | 471,000 |  |
Shares issued for exercise of options | $ 109 |  | 109 |
Shares issued for exercise of options (in shares) | 344,000 | 344,000 |  |
Share-based payment award compensation costs | $ 10,682 |  | 10,682 |
Net loss | (176,145) |  |  | (176,145)
Ending balance, value at Dec. 31, 2019 | 9,201 | $ 271 | 704,351 | (695,421)
Ending balance, shares at Dec. 31, 2019 |  | 271,177,000 |  |
Shares issued for sale of common stock, net of cost | 31,703 | $ 27 | 31,676 |
Shares issued for sale of common stock, net of cost (in shares) |  | 26,953,000 |  |
Shares issued for exercise of options | $ 272 | $ 1 | 271 |
Shares issued for exercise of options (in shares) | 1,182,000 | 1,182,000 |  |
Shares issued for vested restricted and performance stock units |  | $ 1 | (1) |
Shares issued for vested restricted and performance stock units (in shares) |  | 453,000 |  |
Warrants issued in relation to debt financing agreement | $ 7,668 |  | 7,668 |
Share-based payment award compensation costs | 10,679 |  | 10,679 |
Net loss | (183,524) |  |  | (183,524)
Ending balance, value at Dec. 31, 2020 | $ (124,001) | $ 300 | 754,644 | (878,945)
Ending balance, shares at Dec. 31, 2020 | 299,765,000 | 299,765,000 |  |
Shares issued for sale of common stock, net of cost | $ 184,115 | $ 122 | 183,993 |
Shares issued for sale of common stock, net of cost (in shares) |  | 121,765,000 |  |
Shares issued for exercise of warrants, net of cashless exercises | 278 | $ 1 | 277 |
Shares issued for exercise of warrants, net of cashless exercises (in shares) |  | 1,103,000 |  |
Shares issued for exercise of options | $ 44 |  | 44 |
Shares issued for exercise of options (in shares) | 111,000 | 111,000 |  |
Shares issued for vested restricted and performance stock units |  | $ 7 | (7) |
Shares issued for vested restricted and performance stock units (in shares) |  | 6,806,000 |  |
Shares issued for sale of common stock related to employee stock purchase plan | $ 233 |  | 233 |
Shares issued for sale of common stock related to employee stock purchase plan (in shares) |  | 336,000 |  |
Share-based payment award compensation costs | 18,125 |  | 18,125 |
Net loss | (172,415) |  |  | (172,415)
Ending balance, value at Dec. 31, 2021 | $ (93,621) | $ 430 | $ 957,309 | $ (1,051,360)
Ending balance, shares at Dec. 31, 2021 | 429,886,000 | 429,886,000 |  |

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