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Summary quarterly information (unaudited) - Summary of Quarterly Information (Details) - USD ($) $ / shares in Units, $ in Thousands | 3 Months Ended | 12 Months Ended
--- | --- | ---
Dec. 31, 2021 | [1] | Sep. 30, 2021 | [2] | Jun. 30, 2021 | Mar. 31, 2021 | Dec. 31, 2020 | [3] | Sep. 30, 2020 | [4] | Jun. 30, 2020 | Mar. 31, 2020 | Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Quarterly Financial Information Disclosure [Abstract] |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |  |
Total revenue, net | $ 18,678 |  | $ 25,406 |  | $ 23,001 |  | $ 19,866 |  | $ 22,578 |  | $ 19,342 |  | $ 10,701 |  | $ 12,251 |  | $ 86,951 | $ 64,872 | $ 49,647
Gross profit | 13,941 |  | 20,124 |  | 18,869 |  | 15,179 |  | 16,997 |  | 16,063 |  | 6,301 |  | 9,536 |  | 68,113 | 48,897 | 43,312
Loss from operations | (35,392) |  | (39,921) |  | (35,179) |  | (29,278) |  | (34,607) |  | (24,974) |  | (45,038) |  | (50,922) |  | (139,770) | (155,541) | (151,205)
Net loss | $ (42,960) |  | $ (47,420) |  | $ (42,652) |  | $ (39,383) |  | $ (42,087) |  | $ (32,612) |  | $ (51,976) |  | $ (56,849) |  | $ (172,415) | $ (183,524) | $ (176,145)
Loss per common share, basic and diluted | $ (0.10) | [5] | $ (0.11) | [5] | $ (0.11) | [5] | $ (0.11) | [5] | $ (0.15) | [5] | $ (0.12) | [5] | $ (0.19) | [5] | $ (0.21) | [5] | $ (0.43) | $ (0.67) | $ (0.72)
[1] | Included $5.1 million in senior executive severances, which included our former CEO.
[2] | Included $7.3 million in senior executive severances, which included our former EVP of Operations.
[3] | Included $0.5 million in write off of certain costs related to trademarks and patents.
[4] | Included (i) $2.0 million in license revenue related to the Knight License Agreement, (ii) $5.7 million in inventory charge, primarily related to BIJUVA, and (iii) $0.6 million in write off of certain costs related to trademarks and patents.
[5] | Basic and diluted loss per common share are computed independently for each quarter and the full year based upon respective weighted average shares outstanding. Therefore, the sum of the quarterly basic and diluted earnings per share amounts may not equal the annual basic and diluted earnings per share amounts reported.

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