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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash flows from operating activities: |  |  |
Net loss | $ (172,415,000) | $ (183,524,000) | $ (176,145,000)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation and amortization | 4,093,000 | 4,067,000 | 1,392,000
Charges to provision for doubtful accounts | 533,000 | 238,000 | 318,000
Inventory charge | 1,082,000 | 7,205,000 | 0
Debt financing fees | 5,689,000 | 2,532,000 | 856,000
Share-based payment compensation costs | 18,125,000 | 10,679,000 | 10,682,000
Write-off of patent and trademark | 0 | 1,132,000 | 79,000
Loss of extinguishment of debt |  |  | 10,058,000
Other | 720,000 | 1,541,000 | 1,074,000
Changes in operating assets and liabilities: |  |  |
Accounts receivable | (4,327,000) | (8,224,000) | (13,651,000)
Inventory | (711,000) | (3,337,000) | (8,593,000)
Prepaid and other current assets | (3,005,000) | 3,209,000 | (1,734,000)
Accounts payable | (750,000) | 1,887,000 | (3,563,000)
Accrued expenses and other current liabilities | 6,134,000 | 2,904,000 | 13,675,000
Other non-current liabilities | 2,139,000 | 220,000 | (166,000)
Total adjustments | 29,722,000 | 24,053,000 | 10,427,000
Net cash used in operating activities | (142,693,000) | (159,471,000) | (165,718,000)
Cash flows from investing activities: |  |  |
Payment for patent related costs | (2,189,000) | (1,391,000) | (1,442,000)
Payment for intellectual property license |  |  | (20,000,000)
Purchase of fixed assets | (34,000) | (207,000) | (2,450,000)
Net cash used in investing activities | (2,223,000) | (1,598,000) | (23,892,000)
Cash flows from financing activities: |  |  |
Proceeds from sale of common stock, net of costs | 184,115,000 | 31,703,000 | 77,031,000
Proceeds from exercise of options and warrants | 322,000 | 272,000 | 109,000
Proceeds from sale of common stock related to employee stock purchase plan | 233,000 |  |
Repayments of debt | (50,000,000) |  | (81,661,000)
Borrowings of debt |  | 50,000,000 | 200,000,000
Payment of debt financing fees | (5,118,000) | (1,250,000) | (6,652,000)
Net cash provided by financing activities | 129,552,000 | 80,725,000 | 188,827,000
Net decrease in cash | (15,364,000) | (80,344,000) | (783,000)
Cash, beginning of period | 80,486,000 | 160,830,000 | 161,613,000
Cash, end of period | 65,122,000 | 80,486,000 | 160,830,000
Supplemental disclosure of cash flow information: |  |  |
Interest paid | $ 25,068,000 | 25,849,000 | $ 17,788,000
Supplemental disclosure of noncash financing activities: |  |  |
Warrants issued in relation to debt financing agreement |  | $ 7,668,000 |

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