Exhibit 31.1

CERTIFICATION OF CHIEF EXECUTIVE OFFICER

I, Hugh O’Dowd, certify that:

(1) I have reviewed this Annual Report on Form 10-K/A of TherapeuticsMD, Inc. (the “10-K/A Report”);

(2) Based on my knowledge, this 10-K/A Report does not contain any untrue statement of a material fact or omit to state a material fact necessary to make the statements made, in light of the circumstances under which such statements were made, not misleading with respect to the period covered by this report;

(3) [Omitted];

(4) [Omitted]; and

(5) [Omitted].

Date: April 29, 2022

/s/ Hugh O’Dowd

Hugh O’Dowd

Chief Executive Officer