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CONSOLIDATED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2021 | Dec. 31, 2020 | Dec. 31, 2019
Cash Flows from Operating Activities: |  |  |
Net loss | $ (336) | $ (22,397) | $ (107,500)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Depreciation | 85 | 122 | 219
Share-based compensation | 5,143 | 1,757 | 1,237
Change in fair value of contingent consideration | (56,840) | (11,180) | 71,620
Intangibles impairment charge | 31,700 | 0 | 0
Changes in operating assets and liabilities: |  |  |
Accounts receivable (net) | (24,493) | 0 | 0
Prepaid expenses and other assets | (17,964) | (1,304) | (5,188)
Accounts payable | (249) | 1,200 | 535
Accrued expenses and other liabilities | (4,424) | (2,035) | 1,556
Deferred revenue | (1,500) | 3,000 | 0
Net cash used in operating activities | (68,878) | (30,837) | (37,521)
Cash Flows from Investing Activities: |  |  |
Purchases of equipment | (4) | (8) | (136)
Net cash used in investing activities | (4) | (8) | (136)
Cash Flows from Financing Activities: |  |  |
Proceeds from issuance of common stock and common stock warrants, net of issuance costs | 0 | 0 | 27,833
Proceeds from exercises of common stock warrants | 1,126 | 131 | 5,481
Proceeds from issuance of common stock under ATM Offering, net of issuance costs | 174,962 | 37,958 | 1,936
Proceeds from exercises of stock options | 42 | 13 | 98
Proceeds from sale of common stock pursuant to ESPP | 0 | 11 | 8
Net cash provided by financing activities | 176,129 | 38,113 | 35,356
Net increase (decrease) in cash, cash equivalents and restricted cash | 107,247 | 7,268 | (2,301)
Cash, cash equivalents and restricted cash - beginning of period | 55,409 | 48,141 | 50,442
Cash, cash equivalents and restricted cash - end of period | 162,656 | 55,409 | 48,141
Reconciliation of cash, cash equivalents and restricted cash: |  |  |
Cash and cash equivalents | 162,636 | 52,389 | 48,121
Short term restricted cash | 0 | 3,000 | 0
Long term restricted cash | 20 | 20 | 20
Total cash, cash equivalents and restricted cash | 162,656 | 55,409 | 48,141
Supplemental cash flow disclosure: |  |  |
Cash paid for amounts included in the measurement of lease liabilities | 174 | 154 | 153
Supplemental disclosure of non-cash operating activities: |  |  |
Right-of-use assets related to the adoption of ASC 842 | 0 | 0 | 236
Right-of-use assets obtained in exchange for lease obligations | 0 | 290 | 0
Supplemental disclosure of non-cash financing activities: |  |  |
Deemed Dividend on adjustment of exercise price on certain warrants | $ 0 | $ 147 | $ 0

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