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SHARE-BASED COMPENSATION (Tables) | 6 Months Ended | 12 Months Ended
--- | --- | ---
Jun. 30, 2022 | Dec. 31, 2021
Share-based Payment Arrangement [Abstract] |  |
Schedule of Share-Based Compensation Expense | The following table sets forth the amount of share-based compensation expense recognized by the Company by line item on its Condensed Consolidated Statements of Operations for the three and six months ended June 30, 2022 and 2021 (in thousands):
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Three Months Ended |  | Six Months Ended
​ | ​ | June 30, | ​ | June 30,
​ |  | 2022 |  | 2021 |  | 2022 |  | 2021
Research and development | ​ | $ | 473 | ​ | $ | 207 | ​ | $ | 975 | ​ | $ | 386
General and administrative | ​ |  | 1,329 | ​ |  | 1,052 | ​ |  | 2,721 | ​ |  | 1,831
Total Share Based Compensation | ​ | $ | 1,802 | ​ | $ | 1,259 | ​ | $ | 3,696 | ​ | $ | 2,217
| The following table sets forth the amount of share-based compensation expense recognized by the Company by line item on its Consolidated Statements of Operations and Comprehensive Loss for the years ended December 31, 2021, 2020 and 2019 (in thousands):
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | Year ended December 31,
​ |  | 2021 |  | 2020 |  | 2019
Research and development | ​ | $ | 973 | ​ | $ | 350 | ​ | $ | 188
General and administrative | ​ |  | 4,170 | ​ |  | 1,407 | ​ |  | 1,049
Total Share Based Compensation | ​ | $ | 5,143 | ​ | $ | 1,757 | ​ | $ | 1,237
Schedule of the Status of Restricted Stock Units | The following table sets forth a summary of the Company’s RSU and PSU activity for the six months ended June 30, 2022:
​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Restricted Stock | ​ | Weighted Average
​ | ​ | Units | ​ | Grant Date Fair
​ |  | (in thousands) |  | Value
Unvested at December 31, 2021 | ​ | 3,041 | ​ | $ | 0.80
Granted RSU | ​ | 4,161 | ​ | $ | 0.68
Cancelled RSU |  | (143) | ​ | $ | 0.75
Granted PSU |  | 1,004 | ​ | $ | 0.67
Unvested at June 30, 2022 |  | 8,063 | ​ | $ | 0.72
| ​
​ | ​ | ​
​ |  | Restricted Stock Units (in thousands)
Unvested at December 31, 2020 |  | —
Granted RSU |  | 2,482
Granted PSU |  | 559
Unvested at December 31, 2021 |  | 3,041
Schedule of Stock Option Activity | The following table sets forth a summary of the Company’s total stock option activity, including awards granted under the 2014 Plan and the 2009 Plan and inducement grants made outside of stockholder approved plans, for the six months ended June 30, 2022:
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | Weighted- | ​ | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | Average | ​ | ​ | ​
​ | ​ | Number of | ​ | ​ | ​ | ​ | Remaining | ​ | Aggregate
​ | ​ | Shares under | ​ | Weighted- | ​ | Contractual | ​ | Intrinsic
​ | ​ | Option | ​ | Average | ​ | Life | ​ | Value
​ |  | (in thousands) |  | Exercise Price |  | (in years) |  | (in thousands)
Outstanding at December 31, 2021 | ​ | 15,703 | ​ | $ | 1.93 | ​ | ​ | 8.03 | ​ | $ | 82
Granted | ​ | 1,511 | ​ | $ | 0.72 | ​ | ​ |  | ​ |  | ​
Exercised | ​ | — | ​ | ​ | — | ​ | ​ |  | ​ |  | ​
Canceled or forfeited | ​ | (53) | ​ | ​ | 1.20 | ​ | ​ |  | ​ |  | ​
Outstanding at June 30, 2022 | ​ | 17,161 | ​ | $ | 1.83 | ​ | ​ | 7.72 | ​ | $ | 218
Exercisable at June 30, 2022 |  | 9,555 | ​ | $ | 1.72 | ​ |  | 7.11 | ​ | $ | 64
| ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ |  | Weighted- |  | ​ | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | Average | ​ | ​ | ​
​ | ​ | Number of | ​ | ​ | ​ | ​ | Remaining | ​ | Aggregate
​ | ​ | Shares under | ​ | Weighted- | ​ | Contractual | ​ | Intrinsic
​ | ​ | Option | ​ | Average | ​ | Life | ​ | Value
​ | ​ | (in thousands) | ​ | Exercise Price | ​ | (in years) | ​ | (in thousands)
Outstanding at December 31, 2018 |  | 3,942 | ​ | $ | 2.12 |  | 9.14 | ​ | $ | 57
Granted |  | 3,986 | ​ | $ | 1.02 |  |  | ​ |  |
Exercised |  | (90) | ​ | $ | 1.10 |  |  | ​ |  |
Canceled or forfeited |  | (1,602) | ​ | $ | 1.78 |  |  | ​ |  |
Outstanding at December 31, 2019 |  | 6,236 | ​ | $ | 1.52 |  | 8.83 | ​ | $ | 358
Granted |  | 4,044 | ​ | $ | 0.87 |  |  | ​ |  |
Exercised |  | (12) | ​ | $ | 1.13 |  |  | ​ |  |
Canceled or forfeited |  | (121) | ​ | $ | 1.04 |  |  | ​ |  |
Outstanding at December 31, 2020 |  | 10,147 | ​ | $ | 1.26 |  | 8.50 | ​ | $ | 3,160
Granted |  | 8,273 | ​ | $ | 3.32 |  |  | ​ |  |
Exercised |  | (34) | ​ | $ | 1.23 |  |  | ​ |  |
Canceled or forfeited |  | (2,683) | ​ | $ | 3.70 |  |  | ​ |  |
Outstanding at December 31, 2021 |  | 15,703 | ​ | $ | 1.93 |  | 8.03 | ​ | $ | 82
Exercisable at December 31, 2021 |  | 7,562 | ​ | $ | 1.65 |  | 7.41 | ​ | $ | 59
Schedule of Weighted-Average Inputs and Assumptions in Black-Scholes Option | For the six months ended June 30, 2022 and 2021, the grant-date fair value of stock options was determined using the following weighted-average inputs and assumptions in the Black-Scholes option pricing model:
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | June 30, 2022 |  | June 30, 2021 |
Fair market value | ​ | $ | 0.72 | ​ | $ | 3.34 | ​
Grant exercise price | ​ | $ | 0.72 | ​ | $ | 3.34 | ​
Expected term (in years) | ​ |  | 6.0 | ​ |  | 6.04 | ​
Risk-free interest rate | ​ |  | 2.1 | % |  | 0.9 | %
Expected volatility | ​ |  | 71.8 | % |  | 74.7 | %
Dividend yield | ​ |  | — | % |  | — | %
| ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | Year ended December 31,
​ |  | 2021 |  | 2020 |  | 2019 |
Fair market value | ​ | $ | 3.32 | ​ | $ | 0.87 | ​ | $ | 1.02 | ​
Grant exercise price | ​ | $ | 3.32 | ​ | $ | 0.87 | ​ | $ | 1.02 | ​
Expected term (in years) | ​ |  | 6.0 | ​ |  | 6.1 | ​ |  | 6.0 | ​
Risk-free interest rate | ​ |  | 0.9 | % |  | 1.3 | % |  | 2.1 | %
Expected volatility | ​ |  | 74.6 | % |  | 71.5 | % |  | 78.1 | %
Dividend yield | ​ |  | — | % |  | — | % |  | — | %

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