    <SEC-DOCUMENT>0001485003-22-000062-index.html : 20220509
    <SEC-HEADER>0001485003-22-000062.hdr.sgml : 20220509
    <ACCEPTANCE-DATETIME>20220509080146
    ACCESSION NUMBER:		0001485003-22-000062
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		12
    FILED AS OF DATE:		20220509
    DATE AS OF CHANGE:		20220509

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Sesen Bio, Inc.
    		CENTRAL INDEX KEY:			0001485003
    		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
    		IRS NUMBER:				262025616
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-36296
    		FILM NUMBER:		22903298

    	BUSINESS ADDRESS:
    		STREET 1:		245 FIRST STREET
    		STREET 2:		SUITE 1800
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02142
    		BUSINESS PHONE:		617-444-8550

    	MAIL ADDRESS:
    		STREET 1:		245 FIRST STREET
    		STREET 2:		SUITE 1800
    		CITY:			CAMBRIDGE
    		STATE:			MA
    		ZIP:			02142

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Eleven Biotherapeutics, Inc.
    		DATE OF NAME CHANGE:	20100223
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>sesn-defa14a1q2022earnings.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: sesn-defa14a1q2022earnings.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>sesn-form8xkwith1q2022ea001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: sesn-form8xkwith1q2022ea001.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>sesn-form8xkwith1q2022ea002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: sesn-form8xkwith1q2022ea002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>4
    <FILENAME>sesn-form8xkwith1q2022ea003.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 4 - file: sesn-form8xkwith1q2022ea003.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>5
    <FILENAME>sesn-form8xkwith1q2022ea004.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 5 - file: sesn-form8xkwith1q2022ea004.jpg

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    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>6
    <FILENAME>sesn-form8xkwith1q2022ea005.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 6 - file: sesn-form8xkwith1q2022ea005.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>7
    <FILENAME>sesn-form8xkwith1q2022ea006.jpg
    <TEXT>
    Document 7 - file: sesn-form8xkwith1q2022ea006.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>8
    <FILENAME>sesn-form8xkwith1q2022ea007.jpg
    <TEXT>
    Document 8 - file: sesn-form8xkwith1q2022ea007.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>9
    <FILENAME>sesn-form8xkwith1q2022ea008.jpg
    <TEXT>
    Document 9 - file: sesn-form8xkwith1q2022ea008.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>10
    <FILENAME>sesn-form8xkwith1q2022ea009.jpg
    <TEXT>
    Document 10 - file: sesn-form8xkwith1q2022ea009.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>11
    <FILENAME>sesn-form8xkwith1q2022ea010.jpg
    <TEXT>
    Document 11 - file: sesn-form8xkwith1q2022ea010.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>12
    <FILENAME>sesn-form8xkwith1q2022ea011.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 12 - file: sesn-form8xkwith1q2022ea011.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>