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SHARE-BASED COMPENSATION (Tables)

12 Months Ended

Dec. 31, 2022

Share-Based Payment Arrangement [Abstract]

Schedule of Share-Based Compensation Expense

The following table sets forth the amount of share-based compensation expense recognized by the Company by line item on its Consolidated Statements of Operations and Comprehensive Loss for the years ended December 31, 2022, 2021 and 2020 (in thousands):

			Year Ended December 31,
			2022						2021						2020
Research and development			$	1,985					$	973					$	350
General and administrative			4,924						4,170						1,407
Total Share Based Compensation			$	6,909					$	5,143					$	1,757

Schedule of the Status of Restricted Stock Units

A summary of the status of restricted stock units is presented below:

			Restricted Stock Units (in thousands)
Unvested at December 31, 2021			3,041
Granted RSU			4,160
Granted PSU			1,004
Vested			(3,293)
Canceled or forfeited			(217)
Unvested at December 31, 2022			4,695

Schedule of Stock Option Activity

The following table sets forth a summary of the Company’s total stock option activity, including awards granted under the 2014 Plan and 2009 Plan and inducement grants made outside of stockholder approved plans, for the years ended December 31, 2022, 2021 and 2020:

			Number of Shares under Option (in thousands)						Weighted-Average Exercise Price						Weighted-Average Remaining Contractual  Life (in years)						Aggregate Intrinsic Value (in thousands)
Outstanding at December 31, 2019			6,236						$1.52						8.83						$	358
Granted			4,044						$0.87
Exercised			(12)						$1.13
Canceled or forfeited			(121)						$1.04
Outstanding at December 31, 2020			10,147						$1.26						8.50						$	3,160
Granted			8,273						$3.32
Exercised			(34)						$1.23
Canceled or forfeited			(2,683)						$3.70
Outstanding at December 31, 2021			15,703						$1.93						8.03						$	82
Granted			1,510						$0.72
Exercised			(2)						$0.32
Canceled or forfeited			(1,907)						$1.90
Outstanding at December 31, 2022			15,304						$1.82						7.19						$	3
Exercisable at December 31, 2022			10,427						$1.72						6.77						DM

Schedule of Weighted-Average Inputs and Assumptions in Black-Scholes Option

For the years ended December 31, 2022, 2021 and 2020, the grant-date fair value of stock options was determined using the following weighted-average inputs and assumptions in the Black-Scholes option pricing model:

			Year Ended December 31,
			2022						2021						2020
Fair market value			$0.72						$3.32						$0.87
Grant exercise price			$0.72						$3.32						$0.87
Expected term (in years)			6.0						6.0						6.1
Risk-free interest rate			2.1%						0.9%						1.3%
Expected volatility			71.8%						74.6%						71.5%
Dividend yield			—%						—%						—%

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Tabular disclosure of allocation of amount expensed and capitalized for award under share-based payment arrangement to statement of income or comprehensive income and statement of financial position. Includes, but is not limited to, corresponding line item in financial statement.

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Tabular disclosure of the changes in outstanding nonvested restricted stock units.

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