EX-32.1 5 tmb-20250930xex32d1.htm EX-32.1

Exhibit 32.1

CERTIFICATION PURSUANT TO
18 U.S.C. SECTION 1350, AS ADOPTED PURSUANT TO
SECTION 906 OF THE SARBANES-OXLEY ACT OF 2002

In connection with the Quarterly Report of Carisma Therapeutics Inc. (the “Company”) on Form 10-Q for the period ended September 30, 2025 as filed with the Securities and Exchange Commission on the date hereof (the “Report”), I certify, pursuant to 18 U.S.C. § 1350, as adopted pursuant to § 906 of the Sarbanes-Oxley Act of 2002, that, to my knowledge:

(1) | The Report fully complies with the requirements of section 13(a) or 15(d) of the Securities Exchange Act of 1934; and

(2) | The information contained in the Report fairly presents, in all material respects, the financial condition and results of operations of the Company.

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Date: November 12, 2025 | By: | /s/ Steven Kelly
​ | ​ | Steven Kelly
​ | ​ | President, Chief Executive Officer and Director
​ | ​ | (Principal Executive Officer)

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