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Summary of Significant Accounting Policies (Tables)

6 Months Ended

12 Months Ended

Jun. 30, 2025

Dec. 31, 2024

Accounting Policies [Abstract]

Schedule of Significant Expense Categories by Segment

The table below summarizes the significant expense categories regularly reviewed by the CODM for the three and six months ended June 30, 2025 and 2024 (in thousands):

​	​	​	​	​	​	​	​	​	​	​	​	​
​		Three Months Ended June 30,						Six Months Ended June 30,
​		2025			2024			2025			2024
Collaboration revenues	​	$	—	​	$	9,197	​	$	3,729	​	$	12,594
Less:	​			​			​			​
Research and development, excluding facilities, personnel, depreciation and amortization expenses	​		1,499	​		7,643	​		3,027	​		17,834
General and administrative, excluding facilities and personnel expenses, depreciation and amortization expenses	​		2,836	​		4,070	​		5,257	​		7,726
Facilities expense	​		656	​		1,794	​		1,755	​		3,426
Personnel expense	​		787	​		6,311	​		8,141	​		12,840
Depreciation, amortization and interest on finance and sale-leaseback lease liabilities	​		38	​		1,153	​		750	​		2,338
Other segment items(a)	​		3,958	​		(612)	​		3,839	​		(1,430)
Net loss	​	$	(9,774)	​	$	(11,162)	​	$	(19,040)	​	$	(30,140)

(a) “Other segment items” includes loss on sale of held for sale assets, loss on abandonment of operating lease right-of-use assets, and other income, net.

The table below summarizes the significant expense categories regularly reviewed by the CODM for the years ended December 31, 2024 and 2023:

​	​	​	​	​	​	​
​	​	Years Ended
​	​	December 31,
​		2024			2023
Collaboration revenues	​	$	19,632	​	$	14,919
Less:	​			​
Research and development, excluding facilities, personnel, depreciation and amortization expenses	​		33,147	​		45,905
General and administrative, excluding facilities and personnel expenses, depreciation and amortization expenses	​		14,829	​		19,118
Facilities expense	​		5,917	​		7,671
Personnel expense	​		24,564	​		27,324
Depreciation, amortization and interest on finance and sale-leaseback lease liabilities	​		3,894	​		3,984
Other segment items(a)	​		(2,242)	​		(2,204)
Net loss	​	$	(60,477)	​	$	(86,879)

Schedule of Dilutive Securities

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares of common stock outstanding, as they would be anti-dilutive:

​	​	​	​	​
​		June 30,
​		2025		2024
Stock options		6,420,876		8,685,238

The following potentially dilutive securities have been excluded from the computation of diluted weighted-average shares of common stock outstanding, as they would be anti-dilutive:

​	​	​	​	​
​	​	December 31,
​		2024		2023
Stock options		7,746,991		6,023,370

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Tabular disclosure of securities (including those issuable pursuant to contingent stock agreements) that could potentially dilute basic earnings per share (EPS) in the future that were not included in the computation of diluted EPS because to do so would increase EPS amounts or decrease loss per share amounts for the period presented, by antidilutive securities.

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Tabular disclosure of the profit or loss and total assets for each reportable segment. An entity discloses certain information on each reportable segment if the amounts (a) are included in the measure of segment profit or loss reviewed by the chief operating decision maker or (b) are otherwise regularly provided to the chief operating decision maker, even if not included in that measure of segment profit or loss.

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