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As filed with the Securities and Exchange Commission on August 12, 2009

Registration No. 333-____

UNITED STATES
SECURITIES AND EXCHANGE COMMISSION

Washington, D.C. 20549

FORM S-8

REGISTRATION STATEMENT
Under
The Securities Act of 1933

ELECTRO-OPTICAL SCIENCES, INC.

(Exact Name of Registrant as Specified in its Charter)


Delaware		13-3986004
(State or Other Jurisdiction of Incorporation or
Organization)		(IRS Employer Identification No.)

3 West Man Street, Suite 201
Irvington, New York 10533
(Address of Principal Executive Offices) (Zip Code)

2005 STOCK INCENTIVE PLAN
(Full Title of the Plan)

Joseph V. Gulfo, M.D.
President and Chief Executive Officer
Electro-Optical Sciences, Inc.
3 West Main Street, Suite 201
Irvington, New York 10533
(Name and Address of Agent for Service)

(914) 591-3783
(Telephone Number, Including Area Code, of Agent for Service)

Indicate by check mark whether the registrant is a large accelerated filer, an accelerated filer, a non-accelerated filer, or a smaller reporting company. See the definitions of “large accelerated filer,” “accelerated filer” and “smaller reporting company” in Rule 12b-2 of the Exchange Act. (Check one):


Large accelerated filer o	Accelerated filer þ	Non-accelerated filer o	Smaller reporting company o
		(Do not check if a smaller reporting company)

CALCULATION OF REGISTRATION FEE

Proposed Maximum

Title of Securities to

Amount to be

Offering Price per

Aggregate Offering

Amount of

be Registered

Registered ⁽¹⁾

Price

Registration Fee

Common Stock, $0.001 par value

2,224,028

$7.09 ⁽²⁾

$15,768,358.52

$879.87

(1)		Pursuant to Rule 416 under the Securities Act of 1933, this Registration Statement also covers any additional shares of the Registrant’s Common Stock that becomes issuable under the 2005 Stock Incentive Plan by reason of any stock dividend, stock split, recapitalization or similar event.

(2)		Calculated solely for the purpose of determining the registration fee pursuant to Rule 457 under the Securities Act of 1933 and based upon the average of the high and low prices for the Registrant’s Common Stock as quoted on the NASDAQ Capital Market on August 6, 2009.

TABLE OF CONTENTS


PART I
PART II
	Item 3. Incorporation of Documents by Reference
	Item 8. Exhibits
	Item 9. Undertakings
SIGNATURES
EXHIBIT INDEX
EX-5.1
EX-23.1

INTRODUCTORY NOTE

Pursuant to General Instruction E to Form S-8, this Registration Statement on Form S-8 registers the offer and sale of an additional 2,224,028 shares of common stock of Electro-Optical Sciences, Inc. (the “Registrant”) for issuance under the Registrant’s 2005 Stock Incentive Plan. The contents of the prior Registration Statement on Form S-8 filed with the Securities and Exchange Commission on July 31, 2006 (Registration No. 333-136183), relating to the 2005 Stock Incentive Plan, are incorporated herein by reference, except to the extent modified herein.

PART I

INFORMATION REQUIRED IN THE SECTION 10(a) PROSPECTUS

In accordance with the Note to Part I of Form S-8, the information specified by Part I (Items 1 and 2) is omitted from this Registration Statement.

PART II

INFORMATION REQUIRED IN THE REGISTRATION STATEMENT

Item 3. Incorporation of Documents by Reference

The Registrant hereby incorporates by reference into this Registration Statement the following documents previously filed with the U.S. Securities and Exchange Commission (the “Commission”):

(a) The Registrant’s Annual Report on Form 10-K for the fiscal year ended December 31, 2008;

(b) The Registrant’s Proxy Statement for its 2009 Annual Meeting of Shareholders;

(c) The Registrant’s Quarterly Reports on Form 10-Q for the quarter ended March 31, 2009 and for the quarter ended June 30, 2009;

(d) The Registrant’s Current Reports on Form 8-K filed with the Commission on February 13, 2009, May 8, 2009, June 4, 2009, June 10, 2009, July 14, 2009 and July 17, 2009, and on Form 8-K/A filed with the Commission on July 14, 2009; and

(e) The description of the Registrant’s Common Stock contained in its Registration Statement on Form 8-A and any amendment or report filed subsequent thereto for the purpose of updating such description.

All documents filed by the Registrant pursuant to Sections 13(a), 13(c), 14 and 15(d) of the Securities Exchange Act of 1934, as amended, subsequent to the date hereof and prior to the filing of a post-effective amendment which indicates that all securities offered hereby have been sold or which deregisters all securities remaining unsold shall be deemed to be incorporated by reference herein and to be a part hereof from the respective dates of filing of such documents. The Registrant expressly excludes from such incorporation information furnished pursuant to Item 2.02 or Item 7.01 of any Current Report on Form 8-K. Any document or any statement contained in a document incorporated or deemed to be incorporated herein by reference shall be deemed to be modified or superseded for purposes of this Registration Statement to the extent that a subsequently filed document or a statement contained herein or in any other subsequently filed document which also is or is deemed to be incorporated herein by reference modifies or supersedes such document or such statement. Any such document or statement so modified or superseded shall not be deemed, except as so modified or superseded, to constitute a part of this Registration Statement.

Item 8. Exhibits


Exhibit
Number		Exhibit

5.1		Opinion of Golenbock Eiseman Assor Bell & Peskoe LLP *
10.1		2005 Stock Incentive Plan, as amended **
23.1		Consent of Eisner LLP, Independent Registered Public Accounting Firm *
23.2		Consent of Golenbock Eiseman Assor Bell & Peskoe LLP (contained in Exhibit 5.1)
24.1		Power of Attorney (included in the signature page of this Registration Statement)


*		Filed herewith.

**		Incorporated by reference to Registrant’s Registration Statement on Form S-1, as amended (File No. 333-125517), as filed on August 8, 2005

Item 9. Undertakings

The undersigned registrant hereby undertakes that, for the purpose of determining liability of the registrant under the Securities Act of 1933 to any purchaser in the initial distribution of the securities:

The undersigned registrant undertakes that in a primary offering of securities of the undersigned registrant pursuant to this registration statement, regardless of the underwriting method used to sell the securities to the purchaser, if the securities are offered or sold to such purchaser by means of any of the following communications, the undersigned registrant will be a seller to the purchaser and will be considered to offer or sell such securities to such purchaser:

(i) Any preliminary prospectus or prospectus of the undersigned registrant relating to the offering required to be filed pursuant to Rule 424;

(ii) Any free writing prospectus relating to the offering prepared by or on behalf of the undersigned registrant or used or referred to by the undersigned registrant;

(iii) The portion of any other free writing prospectus relating to the offering containing material information about the undersigned registrant or its securities provided by or on behalf of the undersigned registrant; and

(iv) Any other communication that is an offer in the offering made by the undersigned registrant to the purchaser.

SIGNATURES

Pursuant to the requirements of the Securities Act of 1933, the Registrant certifies that it has reasonable grounds to believe that it meets all of the requirements for filing on Form S-8, and has duly caused this Registration Statement to be signed on its behalf by the undersigned, thereunto duly authorized, in the Village of Irvington, State of New York, on this 12th day of August 2009.


	ELECTRO-OPTICAL SCIENCES, INC.
	By:	/s/ Joseph V. Gulfo, M.D.
		Joseph V. Gulfo, M.D.
		President and Chief Executive Officer

POWER OF ATTORNEY

KNOW ALL MEN BY THESE PRESENTS that each individual whose signature appears below constitutes and appoints Joseph V. Gulfo, M.D. and Richard I. Steinhart and each of them, his or her true and lawful attorneys-in-fact and agents with full power of substitution, for him or her and in his or her name, place and stead, in any and all capacities, to sign any and all amendments (including post-effective amendments) to this Registration Statement on Form S-8, and to file the same, with all exhibits thereto and all documents in connection therewith, with the Commission, granting unto said attorney-in-fact and agents, and each of them, full power and authority to do and perform each and every act and thing requisite and necessary to be done with respect to this Registration Statement, including post-effective amendments, as fully to all intents and purposes as he or she might or could do in person, hereby ratifying and confirming all that said attorneys-in-fact and agents or any of them, or his or their substitute or substitutes, may lawfully do or cause to be done or by virtue hereof.

Pursuant to the requirements of the Securities Act of 1933, this Registration Statement has been signed by the following persons in the capacities and on the date indicated.


Name and Signature	Title	Date

/s/ Joseph V. Gulfo	Director, President and Chief Executive	August 12, 2009
Joseph V. Gulfo	Officer (Principal Executive Officer)

/s/ Richard I. Steinhart	Vice President, Finance and Chief Financial	August 12, 2009
Richard I. Steinhart	Officer (Principal Financial and Accounting Officer)

/s/ Breaux Castleman	Chairman of the Board of Directors	August 12, 2009
Breaux Castleman

/s/ Sidney Braginsky	Director	August 12, 2009
Sidney Braginsky

/s/ George C. Chryssis	Director	August 12, 2009
George C. Chryssis

/s/ Martin D. Cleary	Director	August 12, 2009
Martin D. Cleary

/s/ Anne Egger	Director	August 12, 2009
Anne Egger

/s/ Dan W. Lufkin	Director	August 12, 2009
Dan W. Lufkin

/s/ Gerald Wagner, PHD.	Director	August 12, 2009
Gerald Wagner, PhD.

EXHIBIT INDEX


Exhibit
Number		Exhibit

5.1		Opinion of Golenbock Eiseman Assor Bell & Peskoe LLP *
10.1		2005 Stock Incentive Plan, as amended **
23.1		Consent of Eisner LLP, Independent Registered Public Accounting Firm *
23.2		Consent of Golenbock Eiseman Assor Bell & Peskoe LLP (contained in Exhibit 5.1)
24.1		Power of Attorney (included in the signature page of this Registration Statement)


*		Filed herewith.

**		Incorporated by reference to Registrant’s Registration Statement on Form S-1, as amended (File No. 333-125517), as filed on August 8, 2005

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