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Stock-based compensation, Stock Options Plan by Exercise Price Range (Details)
 12 Months Ended
Dec. 31, 2016
$ / shares
shares
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]  
Outstanding number of shares (in shares) | shares 4,500,522
Weighted average remaining contractual life 9 years 2 months 1 day
Weighted average exercise price (in dollars per share) $ 1.02
Exercisable number of shares (in shares) | shares 2,200,672
Exercisable weighted average exercise price (in dollars per share) $ 1.48
$0 - $1.25 [Member]  
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]  
Lower range limit (in dollars per share) 0
Upper range limit (in dollars per share) $ 1.25
Outstanding number of shares (in shares) | shares 3,827,500
Weighted average remaining contractual life 9 years 4 months 28 days
Weighted average exercise price (in dollars per share) $ 0.80
Exercisable number of shares (in shares) | shares 1,530,000
Exercisable weighted average exercise price (in dollars per share) $ 1.14
$1.26 - $5.00 [Member]  
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]  
Lower range limit (in dollars per share) 1.26
Upper range limit (in dollars per share) $ 5.00
Outstanding number of shares (in shares) | shares 625,000
Weighted average remaining contractual life 7 years 11 months 5 days
Weighted average exercise price (in dollars per share) $ 1.58
Exercisable number of shares (in shares) | shares 625,000
Exercisable weighted average exercise price (in dollars per share) $ 1.58
$5.01 - $10.00 [Member]  
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]  
Lower range limit (in dollars per share) 5.01
Upper range limit (in dollars per share) $ 10.00
Outstanding number of shares (in shares) | shares 36,022
Weighted average remaining contractual life 6 years 9 months 11 days
Weighted average exercise price (in dollars per share) $ 7.06
Exercisable number of shares (in shares) | shares 34,597
Exercisable weighted average exercise price (in dollars per share) $ 7.08
$10.01 - $63.00 [Member]  
Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range [Line Items]  
Lower range limit (in dollars per share) 10.01
Upper range limit (in dollars per share) $ 63.00
Outstanding number of shares (in shares) | shares 12,000
Weighted average remaining contractual life 5 years 7 months 6 days
Weighted average exercise price (in dollars per share) $ 24.19
Exercisable number of shares (in shares) | shares 11,075
Exercisable weighted average exercise price (in dollars per share) $ 24.27