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STOCK-BASED COMPENSATION - Stock Option Activity (Details) - Common stock options - $ / shares
3 Months Ended 12 Months Ended
Mar. 31, 2022
Dec. 31, 2021
Number of Shares Outstanding, Beginning Balance 7,686,233  
Number of Shares, Granted 1,820,000  
Number of Shares, Cancelled / Expired (117,082)  
Number of Shares Outstanding, Ending Balance 9,389,151 7,686,233
Number of Shares, Options vested and exercisable 4,798,325  
Weighted Average Exercise Price per Share Outstanding, Beginning Balance $ 5.47  
Weighted Average Exercise Price per Share, Granted 0.51  
Weighted Average Exercise Price per Share, Cancelled / Expired 2.60  
Weighted Average Exercise Price per Share Outstanding, Ending Balance 4.54 $ 5.47
Weighted Average Exercise Price, Options vested and exercisable $ 6.48  
Weighted Average Remaining Contractual Life, Outstanding 7 years 10 months 24 days 7 years 8 months 12 days
Weighted Average Remaining Contractual Life, Options granted 9 years 9 months 18 days  
Weighted Average Remaining Contractual Life, Options vested and exercisable 7 years 1 month 6 days