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STOCK OPTION PLANS - Stock-based compensation expenses (Details) - USD ($) | 12 Months Ended
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Dec. 31, 2022 | Dec. 31, 2021
STOCK-BASED COMPENSATION |  |
Total stock compensation expenses | $ 5,344,000 | $ 5,964,000
Research and development |  |
STOCK-BASED COMPENSATION |  |
Total stock compensation expenses | 2,691,000 | 2,856,000
General and administrative |  |
STOCK-BASED COMPENSATION |  |
Total stock compensation expenses | $ 2,653,000 | $ 3,108,000

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- Definition Amount of expense for award under share-based payment arrangement. Excludes amount capitalized. + References Reference 1: http://www.xbrl.org/2003/role/disclosureRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (h)(1)(i) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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