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STOCK OPTION PLANS (Tables) | 12 Months Ended
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Dec. 31, 2022
STOCK OPTION PLANS |
Summary of the company's stock option activity | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | ​ |  | ​ | ​ | ​ | ​ | ​ |  | Weighted Average
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | ​ | Remaining
​ | ​ | ​ | ​ | Weighted Average | ​ | ​ | ​ | ​ | Contractual
​ |  | Number of Shares |  | Exercise Price |  | Total Intrinsic Value |  | Life (in years)
Outstanding as of January 1, 2021 |  | 600,181 | ​ | $ | 62.18 | ​ | $ | — | ​ | 8.3
Granted |  | 191,500 | ​ | ​ | 28.97 | ​ | ​ | — | ​ | 8.9
Exercised | ​ | (146) | ​ | ​ | 21.20 | ​ | ​ | — | ​ | —
Canceled/Expired |  | (22,912) | ​ | ​ | 35.92 | ​ | ​ | — | ​ | —
Outstanding as of December 31, 2021 |  | 768,623 | ​ | ​ | 54.69 | ​ | ​ | — | ​ | 7.7
Granted |  | 260,000 | ​ |  | 4.68 | ​ |  | — | ​ | 7.8
Canceled/Expired |  | (142,450) | ​ |  | 36.78 | ​ |  | — | ​ | —
Outstanding as of December 31, 2022 |  | 886,173 | ​ | $ | 42.90 | ​ | $ | — | ​ | 7.3
Options vested and exercisable |  | 560,929 | ​ | $ | 59.39 | ​ | $ | — | ​ | 6.6
​
Schedule or description of weighted average discount rate | ​
​ | ​ | ​ | ​ | ​ | ​ | ​ | ​
​ | ​ | For the Years Ended | ​
​ | ​ | December 31, | ​
​ |  | 2022 |  | 2021 | ​
Exercise price | ​ | $ | 4.70 | ​ | $ | 29.00 | ​
Expected term (years) | ​ |  | 5.9 | ​ |  | 6.0 | ​
Expected stock price volatility | ​ |  | 85 | % |  | 94 | %
Risk-free rate of interest | ​ |  | 2 | % |  | 1 | %
Expected dividend rate | ​ |  | 0 | % |  | 0 | %
​
Schedule of stock-based compensation expenses | ​
​ | ​ | ​ | ​ | ​ | ​ | ​
​ |  | For the Years Ended
​ | ​ | December 31,
​ |  | 2022 |  | 2021
Stock Compensation expenses: |  | ​ |  |  | ​ |
Research and development | ​ | $ | 2,691,000 | ​ | $ | 2,856,000
General and administrative | ​ |  | 2,653,000 | ​ |  | 3,108,000
Total stock compensation expenses | ​ | $ | 5,344,000 | ​ | $ | 5,964,000
​

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- Definition Tabular disclosure of activity for award under share-based payment arrangement. Includes, but is not limited to, outstanding award at beginning and end of year, granted, exercised, forfeited, and weighted-average grant date fair value. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (e) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (c)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (d) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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- Definition Tabular disclosure of the significant assumptions used during the year to estimate the fair value of stock options, including, but not limited to: (a) expected term of share options and similar instruments, (b) expected volatility of the entity's shares, (c) expected dividends, (d) risk-free rate(s), and (e) discount for post-vesting restrictions. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2 -Subparagraph (f)(2) -URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901 + Details
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