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STOCK OPTION PLANS - Stock-based compensation expenses (Details) - USD ($)	12 Months Ended
	Dec. 31, 2022	Dec. 31, 2021
STOCK-BASED COMPENSATION
Total stock compensation expenses	$ 5,344,000	$ 5,964,000
Research and development
STOCK-BASED COMPENSATION
Total stock compensation expenses	2,691,000	2,856,000
General and administrative
STOCK-BASED COMPENSATION
Total stock compensation expenses	$ 2,653,000	$ 3,108,000

X

- Definition

Line items represent stock-based compensation.

+ References

No definition available.

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- Definition

Amount of expense for award under share-based payment arrangement. Excludes amount capitalized.

+ References

Reference 1: http://www.xbrl.org/2003/role/disclosureRef
-Publisher FASB
-Name Accounting Standards Codification
-Topic 718
-SubTopic 10
-Section 50
-Paragraph 2
-Subparagraph (h)(1)(i)
-URI https://asc.fasb.org/extlink&oid=128089324&loc=d3e5070-113901

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