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Consolidated Statements of Stockholders' Equity (Deficit) - USD ($)
Series A Convertible Preferred Stock [Member]
Preferred Stock [Member]
Series B Convertible Preferred Stock [Member]
Preferred Stock [Member]
Common Stock [Member]
Additional Paid-in Capital [Member]
Retained Earnings [Member]
Total
Beginning balance, value at Dec. 31, 2020 $ 72 $ 88,511,269 $ (89,842,833) $ (1,331,492)
Beginning balance, shares at Dec. 31, 2020 715,544      
Shares and warrants issued for cash related to public offering, net $ 230 21,072,453 21,072,683
Shares and warrants issued for cash related to public offering, net, shares     2,300,000      
Shares issued in connection with the public offering in exchange for notes payable, accrued interest and outstanding warrants $ 15,432 $ 31 22,611,982 22,627,445
Shares issued in connection with the public offering in exchange for notes payable, accrued interest and outstanding warrants, shares 1,543,158   313,789      
Shares issued in exchange of notes payable and accrued interest $ 1 317,376 317,377
Shares issued in exchange for notes payable and accrued interest, shares     8,069      
Shares issued in cashless exercise of warrants $ 18 (82,146) (82,128)
Shares issued in cashless exercise of warrants, shares     177,239      
Shares issued in litigation settlement 21,000 21,000
Shares issued in litigation settlement, shares     750      
Fair market value of beneficial conversion feature and warrants issued with convertible notes payable instruments 166,404 166,404
     - restricted share units 3,671,503 3,671,503
restricted stock units, shares   116,486      
     - options 19,411,976 19,411,976
options, shares        
     - common stock $ 1 25,475 25,476
common stock, shares     5,000      
Net loss (44,303,295) (44,303,295)
Ending balance, value at Dec. 31, 2021 $ 15,432 $ 353 155,727,292 (134,146,128) 21,596,949
Ending balance, shares at Dec. 31, 2021 1,543,158 3,520,391      
     - restricted share units $ 11 4,735,097 4,735,108
     - options 7,741,864 7,741,864
     - common stock $ 2 135,888 135,890
common stock, shares     15,898      
Net loss (18,494,769) (18,494,769)
Issuance of Series B Preferred Stock in exchange for Series A Preferred Stock $ (15,432) $ 15,432
Issuance of Series B Preferred Stock in exchange for Series A Preferred Stock, Shares (1,543,158) 1,543,158        
Warrants issued in connection with license exclusivity agreement 117,030 117,030
Common stock issued in exchange for Series B  Preferred Stock $ (250) $ 3 247
Common stock issued in exchange for Series B Preferred Stock, Shares   (25,000) 25,000      
Ending balance, value at Dec. 31, 2022 $ 15,182 $ 369 $ 168,457,418 $ (152,640,897) $ 15,832,072
Ending balance, shares at Dec. 31, 2022   1,518,158 3,677,775