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STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2019 | Dec. 31, 2018
Cash Flows from Operating Activities: |  |
Net loss | $ (46,389) | $ (30,662)
Accretion of debt discount | 710 | 0
Issuance of common shares - Equity fee on At-the-Market Offering to Fortress Biotech | 495 | 0
Issuance of common shares - Equity fee on Public Offering to Fortress Biotech | 791 | 0
Issuance of common shares - Equity fee on Horizon Notes to Fortress Biotech | 375 | 0
Common shares issuable for Founders Agreement | 4,923 | 2,085
Research and development - licenses acquired | 1,350 | 1,275
Stock-based compensation expenses | 2,664 | 4,960
Depreciation expense | 1,258 | 630
Amortization of operating lease right-of-use assets | 110 | 0
Changes in operating assets and liabilities: |  |
Prepaid expenses and other current assets | (558) | (757)
Interest receivables | 0 | (35)
Other receivables - related party | (19) | 0
Accounts payable and accrued expenses | 296 | 2,470
Payable and accrued expenses - related party | 360 | 99
Deferred rent | 0 | 691
Lease liabilities | 53 | 0
Net cash used in operating activities | (33,581) | (19,244)
Cash Flows from Investing Activities: |  |
Purchase of short-term investment (certificates of deposit) | 0 | (52,500)
Maturity of certificate of deposit | 17,604 | 61,002
Purchase of research and development licenses | (1,350) | (1,075)
Purchase of fixed assets | (2,345) | (6,870)
Net cash provided by investing activities | 13,909 | 557
Cash Flows from Financing Activities: |  |
Proceeds from Horizon Notes | 15,000 | 0
Debt issuance costs | (1,393) | 0
Proceeds from exercise of warrants | 0 | 181
Proceeds from issuance of common shares - At-the-Market Offering | 22,515 | 0
Offering costs for the issuance of common shares - At-the-Market Offering | (543) | 0
Proceeds from issuance of common shares - Public Offering | 31,625 | 0
Offering costs for the issuance of common shares - Public Offering | (2,088) | 0
Net cash provided by financing activities | 65,116 | 181
Net change in cash, cash equivalents and restricted cash | 45,444 | (18,506)
Cash, cash equivalents and restricted cash, beginning of the period | 16,969 | 35,475
Cash, cash equivalents and restricted cash, end of the period | 62,413 | 16,969
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 1,057 | 0
Supplemental disclosure of noncash investing and financing activities: |  |
Fixed assets (acquired but not paid) | 187 | 196
Issuance of common shares - Founders Agreement | 2,085 | 9,558
Research and development licenses included in accounts payable and accrued expenses | 0 | 200
Issuance of warrants - Horizon Notes | $ 888 | $ 0

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