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CONDENSED STATEMENTS OF CASH FLOWS - USD ($) $ in Thousands | 9 Months Ended
--- | ---
Sep. 30, 2021 | Sep. 30, 2020
Cash Flows from Operating Activities: |  |
Net loss | $ (46,321) | $ (39,407)
Adjustments to reconcile net loss to net cash used in operating activities: |  |
Issuance of common shares - Equity fee on At-the-Market Offering to Fortress Biotech | 1,661 | 652
Issuance of common shares - Equity fee on Public Offering to Fortress Biotech | 0 | 932
Research and development - licenses acquired | 1,630 | 1,837
Stock-based compensation expenses | 2,427 | 2,368
Depreciation expense | 1,512 | 1,223
Accretion of debt discount | 0 | 2,321
Amortization of operating lease right-of-use assets | 102 | 81
Changes in operating assets and liabilities: |  |
Prepaid expenses and other assets | 717 | 1,594
Other receivables - related party | (26) | (325)
Accounts payable and accrued expenses | (525) | 978
Payable and accrued expenses - related party | (194) | (291)
Deferred income | 270 | 0
Lease liabilities | (217) | 193
Net cash used in operating activities | (38,964) | (27,844)
Cash Flows from Investing Activities: |  |
Purchase of research and development licenses | (1,280) | (1,720)
Purchase of fixed assets | (2,609) | (1,228)
Net cash used in investing activities | (3,889) | (2,948)
Cash Flows from Financing Activities: |  |
Proceeds from issuance of common shares - At-the-Market Offering | 66,912 | 25,570
Offering costs for the issuance of common shares - At-the-Market Offering | (1,293) | (487)
Proceeds from issuance of common shares - Public Offering | 0 | 37,230
Offering costs for the issuance of common shares - Public Offering | 0 | (2,282)
Repayment of notes payable | 0 | (15,750)
Proceeds from issuance of common shares under ESPP | 309 | 349
Net cash provided by financing activities | 65,928 | 44,630
Net change in cash, cash equivalents and restricted cash | 23,075 | 13,838
Cash, cash equivalents and restricted cash, beginning of the period | 98,804 | 62,413
Cash, cash equivalents and restricted cash, end of the period | 121,879 | 76,251
Supplemental disclosure of cash flow information: |  |
Cash paid for interest | 0 | 1,577
Supplemental disclosure of noncash investing and financing activities: |  |
Fixed assets (acquired but not paid) | 1,376 | 317
Issuance of common shares - Founders Agreement | 7,577 | 4,923
Research and development licenses included in accounts payable and accrued expenses | 350 | 117
Lease liabilities arising from obtaining right-of-use assets | 81 | 0
Offering costs for the issuance of common shares - Public Offering, in accounts payable and accrued expenses | $ 0 | $ 161

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- Definition The cash outflow for cost incurred directly with the issuance of an equity security. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3291-108585 + Details
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- Definition The cash outflow to acquire asset without physical form usually arising from contractual or other legal rights, excluding goodwill. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow (outflow) from long-term debt supported by a written promise to pay an obligation. + References Reference 1: http://www.xbrl.org/2009/role/commonPracticeRef -Publisher FASB -Name Accounting Standards Codification -Topic 235 -SubTopic 10 -Section S99 -Paragraph 3 -Subparagraph (SX 210.12-04(a)) -URI http://asc.fasb.org/extlink&oid=120395691&loc=d3e24072-122690 + Details
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- Definition The cash inflow associated with the amount received from the stock plan during the period. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3255-108585 + Details
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- Definition Amount of noncash expense for share-based payment arrangement. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=121586364&loc=d3e3602-108585 + Details
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- Definition The fair value of stock issued in noncash financing activities. + References Reference 1: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 3 -URI http://asc.fasb.org/extlink&oid=121583591&loc=d3e4304-108586 Reference 2: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 5 -URI http://asc.fasb.org/extlink&oid=121583591&loc=d3e4332-108586 Reference 3: http://fasb.org/us-gaap/role/ref/legacyRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 50 -Paragraph 4 -URI http://asc.fasb.org/extlink&oid=121583591&loc=d3e4313-108586 + Details
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