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Consolidated Statement of Changes in Stockholders' Equity (Parenthetical)
12 Months Ended
Dec. 31, 2018
USD ($)
shares
Statement of Stockholders' Equity [Abstract]  
Common stock, shares exchanged | shares 2,090,301
Conversion of stock, costs $ 82,502
Issuance of common stock units for cash, cost 308,830
Issuance of common stock units for a clinical trial funding commitment, cost $ 168,457