v3.8.0.1

Consolidated Statements of Cash Flows - USD ($) $ in Thousands | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES: |  |  |
Net loss | $ (51,508) | $ (43,157) | $ (24,399)
Adjustments to reconcile net loss to net cash used in operating activities: |  |  |
Non-cash royalty revenue related to royalty monetization | (151) | (7) |
Non-cash interest expense on liability related to royalty monetization | 10,721 | 9,382 | 2,428
Depreciation and amortization | 1,744 | 2,052 | 1,984
Non-cash interest expense related to debt financing | 1,265 | 877 | 897
Stock-based compensation | 4,294 | 4,479 | 5,010
Revaluation of put option and PIPE warrant liabilities | (205) | (767) | (2,136)
Loss on disposal and impairment of property and equipment | 12 |  | 573
Inventory impairment charge | 369 |  |
Other | (5) | 17 | 114
Changes in operating assets and liabilities: |  |  |
Accounts receivable | 4,300 | (2,547) | (3,286)
Inventories | 920 | (1,688) | (466)
Prepaid expenses and other assets | 175 | 975 | (783)
Restricted cash |  |  | 72
Tax receivable | (703) |  |
Accounts payable | 309 | (437) | (786)
Accrued liabilities | (1,301) | 639 | 325
Deferred revenue | (361) | 989 | 784
Deferred rent | 360 | (202) | (284)
Net cash used in operating activities | (29,765) | (29,395) | (19,953)
CASH FLOWS FROM INVESTING ACTIVITIES: |  |  |
Purchase of property and equipment | (2,405) | (3,720) | (1,456)
Purchase of investments | (7,565) | (996) | (7,266)
Proceeds from maturities of investments |  | 6,525 | 16,925
Net cash (used in) provided by investing activities | (9,970) | 1,809 | 8,203
CASH FLOWS FROM FINANCING ACTIVITIES: |  |  |
Proceeds from sale of future royalties |  |  | 61,184
Payment of long-term debt | (3,514) |  | (4,534)
Payment of debt modification transaction costs | (204) | (205) | (215)
Net proceeds from issuance of common stock in connection with equity financings | 15,694 |  |
Net proceeds from issuance of common stock through equity plans | 351 | 179 | 3,199
Net cash provided by (used in) financing activities | 12,327 | (26) | 59,634
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS | (27,408) | (27,612) | 47,884
CASH AND CASH EQUIVALENTS—Beginning of period | 80,310 | 107,922 | 60,038
CASH AND CASH EQUIVALENTS—End of period | 52,902 | 80,310 | 107,922
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION: |  |  |
Cash paid for interest | 2,043 | 1,893 | 2,115
Income taxes (refunded) paid | 2 | (55) | 782
NONCASH INVESTING AND FINANCING ACTIVITIES: |  |  |
Issuance of common stock upon cashless exercise of warrants |  |  | 2,544
Modification of warrants for common stock |  | 45 | 100
Purchases of property and equipment in Accounts payable | 89 | 532 | 98
Purchases of property and equipment in Accrued liabilities | $ 133 |  |

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- Definition The cash outflow associated with the purchase of all investments (debt, security, other) during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash outflow associated with the acquisition of long-lived, physical assets that are used in the normal conduct of business to produce goods and services and not intended for resale; includes cash outflows to pay for construction of self-constructed assets. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 13 -Subparagraph (c) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3213-108585 + Details
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- Definition The cash inflow from the additional capital contribution to the entity. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 + Details
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- Definition Amount of cash inflow from issuance of shares under share-based compensation arrangement. Issuance includes, but is not limited to, exercise of stock options and similar instruments. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 14 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3255-108585 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 718 -SubTopic 10 -Section 50 -Paragraph 2A -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=96867065&loc=SL79508275-113901 + Details
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- Definition The cash inflow associated with the aggregate amount received by the entity through sale or maturity of marketable securities (held-to-maturity or available-for-sale) during the period. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 320 -SubTopic 10 -Section 45 -Paragraph 11 -URI http://asc.fasb.org/extlink&oid=82896770&loc=d3e26853-111562 Reference 2: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 12 -Subparagraph (a),(b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3179-108585 + Details
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- Definition The cash outflow for debt initially having maturity due after one year or beyond the normal operating cycle, if longer. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 15 -Subparagraph (b) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3291-108585 + Details
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- Definition The aggregate amount of noncash, equity-based employee remuneration. This may include the value of stock or unit options, amortization of restricted stock or units, and adjustment for officers' compensation. As noncash, this element is an add back when calculating net cash generated by operating activities using the indirect method. + References Reference 1: http://www.xbrl.org/2003/role/presentationRef -Publisher FASB -Name Accounting Standards Codification -Topic 230 -SubTopic 10 -Section 45 -Paragraph 28 -Subparagraph (a) -URI http://asc.fasb.org/extlink&oid=98514028&loc=d3e3602-108585 + Details
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