v3.8.0.1

Consolidated Statements of Comprehensive Loss - USD ($) | 12 Months Ended
--- | ---
Dec. 31, 2017 | Dec. 31, 2016 | Dec. 31, 2015
Revenue: |  |  |
Collaboration agreement | $ 7,143,000 | $ 6,440,000 | $ 14,857,000
Contract and other | 852,000 | 10,917,000 | 4,406,000
Total revenue | 7,995,000 | 17,357,000 | 19,263,000
Operating costs and expenses: |  |  |
Cost of goods sold | 10,659,000 | 12,315,000 | 1,770,000
Research and development | 19,409,000 | 21,402,000 | 22,488,000
General and administrative | 16,609,000 | 15,597,000 | 14,203,000
Restructuring costs |  |  | 756,000
Total operating costs and expenses | 46,677,000 | 49,314,000 | 39,217,000
Loss from operations | (38,682,000) | (31,957,000) | (19,954,000)
Other (expense) income: |  |  |
Interest expense | (3,316,000) | (2,770,000) | (2,977,000)
Interest income and other income (expense), net | 510,000 | 918,000 | 1,720,000
Non-cash interest expense on liability related to sale of future royalties | (10,721,000) | (9,382,000) | (2,428,000)
Total other (expense) income | (13,527,000) | (11,234,000) | (3,685,000)
Net loss before income taxes | (52,209,000) | (43,191,000) | (23,639,000)
Benefit (provision) for income taxes | 701,000 | 34,000 | (760,000)
Net loss | (51,508,000) | (43,157,000) | (24,399,000)
Other comprehensive income (loss): |  |  |
Unrealized gains (losses) on available for sale securities | (3,000) | 4,000 | 3,000
Comprehensive loss | $ (51,511,000) | $ (43,153,000) | $ (24,396,000)
Net loss per share of common stock, basic (in dollars per share) | $ (1.10) | $ (0.95) | $ (0.55)
Net loss per share of common stock, diluted (in dollars per share) | $ (1.10) | $ (0.95) | $ (0.60)
Shares used in computing net loss per share of common stock, basic (in shares) | 46,883,535 | 45,313,118 | 44,300,099
Shares used in computing net loss per share of common stock, diluted –see Note 14 (in shares) | 46,883,535 | 45,313,118 | 44,468,440

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