Property and Equipment

Property and equipment consist of the following (in thousands):

	As of December 31,
	201 7			201 6
Laboratory equipment	$	3,920		$	3,775
Leasehold improvements		4,469			4,469
Computer equipment and software		241			266
Construction in process		9,703			7,816
Tooling		1,109			1,074
Furniture and fixtures		47			48
		19,489			17,448
Less accumulated depreciation and amortization		(8,438	)		(6,736	)
Property and equipment, net	$	11,051		$	10,712

Depreciation and amortization

expense was

$1.7

million,

$2.1

million and

$2.0

million during the years ended

December

31,

2017,

2016

and

2015,

respectively. Property and equipment, net in the Consolidated Balance Sheets at

December 31, 2017

and

2016,

includes

$0.3

million and

$1.5

million, respectively, related to certain modifications the Company has made at Patheon Pharmaceutical Inc.’s, or Patheon’s, Cincinnati facility under the terms of the Capital Expenditure and Equipment Agreement, or the Capital Agreement.