v3.8.0.1

Note 12 - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2017

Notes Tables

Schedule of Employee Service Share-based Compensation, Allocation of Recognized Period Costs [Table Text Block]

		December 31, 201 7				December 31, 201 6				December 31, 201 5
Cost of goods sold		$	324			$	302			$	67
Research and development			1,901				2,308				2,587
General and administrative			2,069				1,869				2,356
Total		$	4,294			$	4,479			$	5,010

Share-based Compensation, Stock Options, Activity [Table Text Block]

		Number of Stock Options Outstanding				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Life (Years)				Aggregate Intrinsic Value
														(in thousands)
December 31, 2016			6,307,756			$	5.00
Granted			3,007,155				2.99
Forfeited			(438,519	)			4.28
Expired			(351,922	)			7.31
Exercised			(69,372	)			1.52
December 31, 2017			8,455,098			$	4.25				7.1			$	13
Vested and exercisable options —December 31, 2017			4,529,174			$	5.11				5.56			$	13
Vested and expected to vest —December 31, 2017			8,455,098			$	4.25				7.1			$	13

Schedule of Share-based Compensation, Stock Options Outstanding and Exercisable Activity [Table Text Block]

				Options Outstanding												Options Vested and Exercisable
Exercise Prices				Number of Stock Options Outstanding				Weighted-Average Remaining Contractual Life (Years)				Weighted-Average Exercise Price per Share				Shares Subject to Stock Options				Weighted-Average Exercise Price per Share
$1.20	-	$2. 30			105,900				8.4			$	2.13				38,400			$	1.84
$2. 40	-	$3.77			5,592,633				7.7			$	3.10				1,948,300			$	3.17
$ 3.92	-	$6.60			2,060,565				5.7			$	5.45				1,880,190			$	5.36
$8.18	-	$10.55			696,000				6.2			$	10.28				662,284			$	10.28
					8,455,098				7.1			$	4.25				4,529,174			$	5.11

Schedule of Share-based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		201 7					201 6					201 5
Expected term (in years)		5.70					5.25	-	6.25			5.25	-	6.25
Risk-free interest rate		1.82%	-	2.09%			1.24%	-	1.47%			1.35%	-	1.82%
Expected volatility		73%					80%					72%
Expected dividend rate		0%					0%					0%

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