v3.8.0.1
Consolidated Statements of Comprehensive Loss - USD ($)
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Revenue:      
Collaboration agreement $ 7,143,000 $ 6,440,000 $ 14,857,000
Contract and other 852,000 10,917,000 4,406,000
Total revenue 7,995,000 17,357,000 19,263,000
Operating costs and expenses:      
Cost of goods sold 10,659,000 12,315,000 1,770,000
Research and development 19,409,000 21,402,000 22,488,000
General and administrative 16,609,000 15,597,000 14,203,000
Restructuring costs 756,000
Total operating costs and expenses 46,677,000 49,314,000 39,217,000
Loss from operations (38,682,000) (31,957,000) (19,954,000)
Other (expense) income:      
Interest expense (3,316,000) (2,770,000) (2,977,000)
Interest income and other income (expense), net 510,000 918,000 1,720,000
Non-cash interest expense on liability related to sale of future royalties (10,721,000) (9,382,000) (2,428,000)
Total other (expense) income (13,527,000) (11,234,000) (3,685,000)
Net loss before income taxes (52,209,000) (43,191,000) (23,639,000)
Benefit (provision) for income taxes 701,000 34,000 (760,000)
Net loss (51,508,000) (43,157,000) (24,399,000)
Other comprehensive income (loss):      
Unrealized gains (losses) on available for sale securities (3,000) 4,000 3,000
Comprehensive loss $ (51,511,000) $ (43,153,000) $ (24,396,000)
Net loss per share of common stock, basic (in dollars per share) $ (1.10) $ (0.95) $ (0.55)
Net loss per share of common stock, diluted (in dollars per share) $ (1.10) $ (0.95) $ (0.60)
Shares used in computing net loss per share of common stock, basic (in shares) 46,883,535 45,313,118 44,300,099
Shares used in computing net loss per share of common stock, diluted –see Note 14 (in shares) 46,883,535 45,313,118 44,468,440