v3.8.0.1
Consolidated Statements of Cash Flows - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
CASH FLOWS FROM OPERATING ACTIVITIES:      
Net loss $ (51,508) $ (43,157) $ (24,399)
Adjustments to reconcile net loss to net cash used in operating activities:      
Non-cash royalty revenue related to royalty monetization (151) (7)
Non-cash interest expense on liability related to royalty monetization 10,721 9,382 2,428
Depreciation and amortization 1,744 2,052 1,984
Non-cash interest expense related to debt financing 1,265 877 897
Stock-based compensation 4,294 4,479 5,010
Revaluation of put option and PIPE warrant liabilities (205) (767) (2,136)
Loss on disposal and impairment of property and equipment 12 573
Inventory impairment charge 369
Other (5) 17 114
Changes in operating assets and liabilities:      
Accounts receivable 4,300 (2,547) (3,286)
Inventories 920 (1,688) (466)
Prepaid expenses and other assets 175 975 (783)
Restricted cash 72
Tax receivable (703)
Accounts payable 309 (437) (786)
Accrued liabilities (1,301) 639 325
Deferred revenue (361) 989 784
Deferred rent 360 (202) (284)
Net cash used in operating activities (29,765) (29,395) (19,953)
CASH FLOWS FROM INVESTING ACTIVITIES:      
Purchase of property and equipment (2,405) (3,720) (1,456)
Purchase of investments (7,565) (996) (7,266)
Proceeds from maturities of investments 6,525 16,925
Net cash (used in) provided by investing activities (9,970) 1,809 8,203
CASH FLOWS FROM FINANCING ACTIVITIES:      
Proceeds from sale of future royalties 61,184
Payment of long-term debt (3,514) (4,534)
Payment of debt modification transaction costs (204) (205) (215)
Net proceeds from issuance of common stock in connection with equity financings 15,694
Net proceeds from issuance of common stock through equity plans 351 179 3,199
Net cash provided by (used in) financing activities 12,327 (26) 59,634
NET (DECREASE) INCREASE IN CASH AND CASH EQUIVALENTS (27,408) (27,612) 47,884
CASH AND CASH EQUIVALENTS—Beginning of period 80,310 107,922 60,038
CASH AND CASH EQUIVALENTS—End of period 52,902 80,310 107,922
SUPPLEMENTAL DISCLOSURES OF CASH FLOW INFORMATION:      
Cash paid for interest 2,043 1,893 2,115
Income taxes (refunded) paid 2 (55) 782
NONCASH INVESTING AND FINANCING ACTIVITIES:      
Issuance of common stock upon cashless exercise of warrants 2,544
Modification of warrants for common stock 45 100
Purchases of property and equipment in Accounts payable 89 532 98
Purchases of property and equipment in Accrued liabilities $ 133