v3.19.2
Condensed Consolidated Statements of Cash Flows (Unaudited) - USD ($)
 3 Months Ended 6 Months Ended 45 Months Ended
Jun. 30, 2019
Mar. 31, 2019
Jun. 30, 2018
Mar. 31, 2018
Jun. 30, 2019
Jun. 30, 2018
Jun. 30, 2019
Cash flows from operating activities:              
Net loss $ (12,412,000) $ (13,674,000) $ (10,541,000) $ (11,592,000) $ (26,086,000) $ (22,133,000)  
Adjustments to reconcile net loss to net cash used in operating activities:              
Non-cash royalty revenue related to royalty monetization         (118,000) (155,000)  
Non-cash interest (income) expense on liability related to royalty monetization (996,000)   2,995,000   611,000 5,811,000 $ 33,483,000
Depreciation and amortization         734,000 293,000  
Non-cash interest expense related to debt financing         234,000 344,000  
Stock-based compensation         2,453,000 2,128,000  
Other         (212,000) (79,000)  
Changes in operating assets and liabilities:              
Accounts receivable         (172,000) 760,000  
Inventories         (1,990,000) 293,000  
Prepaid expenses and other assets         (632,000) (561,000)  
Other assets         (314,000)  
Accounts payable         559,000 469,000  
Accrued liabilities         (164,000) (837,000)  
Operating lease liabilities         (313,000)  
Deferred rent         65,000  
Deferred revenue         (149,000) (182,000)  
Net cash used in operating activities         (25,559,000) (13,784,000)  
Cash flows from investing activities:              
Purchase of property and equipment         (1,790,000) (387,000)  
Purchase of investments         (28,156,000) (12,844,000)  
Proceeds from maturities of investments         19,700,000 3,600,000  
Net cash used in investing activities         (10,246,000) (9,631,000)  
Cash flows from financing activities:              
Proceeds from issuance of long-term debt         25,000,000  
Payment of costs in connection with refinancing of long-term debt         (190,000)  
Payment of long-term debt         (3,470,000) (3,762,000)  
Extinguishment of debt         (8,864,000)  
Net proceeds from issuance of common stock in connection with equity financings         7,407,000  
Net proceeds from issuance of common stock through equity plans         425,000 141,000  
Net cash provided by financing activities         12,901,000 3,786,000  
Net decrease in cash and cash equivalents         (22,904,000) (19,629,000)  
Cash and cash equivalents—Beginning of period   $ 87,975,000   $ 52,902,000 87,975,000 52,902,000  
Cash and cash equivalents—End of period $ 65,071,000   $ 33,273,000   $ 65,071,000 $ 33,273,000 $ 65,071,000