v3.23.2

Note 15 - Stock-based Compensation (Tables) | 12 Months Ended
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Dec. 31, 2022
Notes Tables |
Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block] |
|  | December 31, 2022 |  |  | December 31, 2021 |
Cost of goods sold |  | $ | — |  |  | $ | 85 |
Research and development |  |  | 570 |  |  |  | 813 |
Selling, general and administrative |  |  | 2,069 |  |  |  | 2,932 |
Discontinued operations |  |  | 250 |  |  |  | 779 |
Total |  | $ | 2,889 |  |  | $ | 4,609 |
Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block] |
|  |  |  |  |  | Weighted |
|  | Number of |  |  | Average |
|  | Restricted |  |  | Grant Date |
|  | Stock Units |  |  | Fair Value |
Restricted stock units outstanding, January 1, 2021 |  |  | 69,890 |  |  | $ | 35.75 |
Granted |  |  | 57,448 |  |  |  | 33.65 |
Vested |  |  | (29,338 | ) |  |  | 37.75 |
Forfeited |  |  | (9,289 | ) |  |  | 31.56 |
Restricted stock units outstanding, December 31, 2021 |  |  | 88,711 |  |  | $ | 34.16 |
Granted |  |  | 58,502 |  |  |  | 7.75 |
Vested |  |  | (44,744 | ) |  |  | 35.46 |
Forfeited |  |  | (19,691 | ) |  |  | 25.00 |
Restricted stock units outstanding, December 31, 2022 |  |  | 82,778 |  |  | $ | 16.97 |
Share-Based Payment Arrangement, Option, Activity [Table Text Block] |
|  | Number of Stock Options Outstanding |  |  | Weighted- Average Exercise Price |  |  | Weighted- Average Remaining Contractual Life (Years) |  |  | Aggregate Intrinsic Value |
|  |  |  |  |  |  |  |  |  |  |  |  |  | (in thousands) |
December 31, 2021 |  |  | 714,085 |  |  | $ | 59.79 |  |  |  |  |  |  |  |  |
Granted |  |  | 117,022 |  |  |  | 7.75 |  |  |  |  |  |  |  |  |
Forfeited |  |  | (35,645 | ) |  |  | 26.46 |  |  |  |  |  |  |  |  |
Expired |  |  | (69,839 | ) |  |  | 60.42 |  |  |  |  |  |  |  |  |
Exercised |  |  | — |  |  |  | — |  |  |  |  |  |  |  |  |
December 31, 2022 |  |  | 725,623 |  |  | $ | 52.98 |  |  |  | 5.3 |  |  | $ | — |
Vested and exercisable options—December 31, 2022 |  |  | 515,933 |  |  | $ | 65.76 |  |  |  | 3.9 |  |  | $ | — |
Vested and expected to vest—December 31, 2022 |  |  | 725,623 |  |  | $ | 52.80 |  |  |  | 5.3 |  |  | $ | — |
Schedule of Share-based Compensation, Stock Options Outstanding and Exercisable Activity [Table Text Block] |
|  |  |  | Options Outstanding |  |  | Options Vested and Exercisable |
Exercise Prices |  | Number of Stock Options Outstanding |  |  | Weighted-Average Remaining Contractual Life (Years) |  |  | Weighted-Average Exercise Price per Share |  |  | Shares Subject to Stock Options |  |  | Weighted-Average Exercise Price per Share |
$4.62 | - | $8.03 |  |  | 88,096 |  |  |  | 9.2 |  |  | $ | 7.54 |  |  |  | — |  |  | $ | — |
$8.36 | - | $12.54 |  |  | 19,046 |  |  |  | 9.1 |  |  | $ | 8.43 |  |  |  | — |  |  | $ | — |
$14.40 | - | $21.60 |  |  | 20,941 |  |  |  | 6.9 |  |  | $ | 16.93 |  |  |  | 13,643 |  |  | $ | 16.84 |
$22.40 | - | $33.60 |  |  | 11,700 |  |  |  | 8.1 |  |  | $ | 28.62 |  |  |  | 10,774 |  |  | $ | 28.58 |
$34.40 | - | $51.60 |  |  | 311,695 |  |  |  | 6.0 |  |  | $ | 41.16 |  |  |  | 217,425 |  |  | $ | 42.75 |
$52.00 | - | $78.00 |  |  | 168,275 |  |  |  | 3.5 |  |  | $ | 62.66 |  |  |  | 168,221 |  |  | $ | 62.66 |
$78.40 | - | $117.60 |  |  | 62,756 |  |  |  | 1.0 |  |  | $ | 97.95 |  |  |  | 62,756 |  |  | $ | 97.95 |
$132.00 | - | $198.00 |  |  | 20,520 |  |  |  | 1.6 |  |  | $ | 133.16 |  |  |  | 20,520 |  |  | $ | 133.16 |
$204.40 | - | $306.60 |  |  | 22,594 |  |  |  | 1.0 |  |  | $ | 206.96 |  |  |  | 22,594 |  |  | $ | 206.96 |
|  |  |  |  | 725,623 |  |  |  | 5.3 |  |  | $ | 52.98 |  |  |  | 515,933 |  |  | $ | 65.76 |
Time-based Stock Option [Member] |
Notes Tables |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Expected term (in years) |  | 6.3 |  |  | 6.0 | - | 6.2 |
Risk-free interest rate |  | 1.6% | - | 3.0% |  |  | 0.9% | - | 1.3% |
Expected volatility |  | 88% |  |  | 90% |
Expected dividend rate |  | 0% |  |  | 0% |
Performance Shares [Member] |
Notes Tables |
Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block] |
|  | Year Ended December 31, |
|  | 2022 |  |  | 2021 |
Derived service period (in years) |  |  | — |  |  | 2.3 | – | 2.6 |
Risk-free interest rate |  |  | — |  |  | 1.5% |
Expected volatility |  |  | — |  |  | 90% |
Expected dividend rate |  |  | — |  |  | 0% |

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