v3.23.2

Note 15 - Stock-based Compensation (Tables)

12 Months Ended

Dec. 31, 2022

Notes Tables

Share-Based Payment Arrangement, Expensed and Capitalized, Amount [Table Text Block]

		December 31, 2022				December 31, 2021
Cost of goods sold		$	—			$	85
Research and development			570				813
Selling, general and administrative			2,069				2,932
Discontinued operations			250				779
Total		$	2,889			$	4,609

Share-Based Payment Arrangement, Restricted Stock and Restricted Stock Unit, Activity [Table Text Block]

						Weighted
		Number of				Average
		Restricted				Grant Date
		Stock Units				Fair Value
Restricted stock units outstanding, January 1, 2021			69,890			$	35.75
Granted			57,448				33.65
Vested			(29,338	)			37.75
Forfeited			(9,289	)			31.56
Restricted stock units outstanding, December 31, 2021			88,711			$	34.16
Granted			58,502				7.75
Vested			(44,744	)			35.46
Forfeited			(19,691	)			25.00
Restricted stock units outstanding, December 31, 2022			82,778			$	16.97

Share-Based Payment Arrangement, Option, Activity [Table Text Block]

		Number of Stock Options Outstanding				Weighted- Average Exercise Price				Weighted- Average Remaining Contractual Life (Years)				Aggregate Intrinsic Value
														(in thousands)
December 31, 2021			714,085			$	59.79
Granted			117,022				7.75
Forfeited			(35,645	)			26.46
Expired			(69,839	)			60.42
Exercised			—				—
December 31, 2022			725,623			$	52.98				5.3			$	—
Vested and exercisable options—December 31, 2022			515,933			$	65.76				3.9			$	—
Vested and expected to vest—December 31, 2022			725,623			$	52.80				5.3			$	—

Schedule of Share-based Compensation, Stock Options Outstanding and Exercisable Activity [Table Text Block]

				Options Outstanding												Options Vested and Exercisable
Exercise Prices				Number of Stock Options Outstanding				Weighted-Average Remaining Contractual Life (Years)				Weighted-Average Exercise Price per Share				Shares Subject to Stock Options				Weighted-Average Exercise Price per Share
$4.62	-	$8.03			88,096				9.2			$	7.54				—			$	—
$8.36	-	$12.54			19,046				9.1			$	8.43				—			$	—
$14.40	-	$21.60			20,941				6.9			$	16.93				13,643			$	16.84
$22.40	-	$33.60			11,700				8.1			$	28.62				10,774			$	28.58
$34.40	-	$51.60			311,695				6.0			$	41.16				217,425			$	42.75
$52.00	-	$78.00			168,275				3.5			$	62.66				168,221			$	62.66
$78.40	-	$117.60			62,756				1.0			$	97.95				62,756			$	97.95
$132.00	-	$198.00			20,520				1.6			$	133.16				20,520			$	133.16
$204.40	-	$306.60			22,594				1.0			$	206.96				22,594			$	206.96
					725,623				5.3			$	52.98				515,933			$	65.76

Time-based Stock Option [Member]

Notes Tables

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		2022					2021
Expected term (in years)		6.3					6.0	-	6.2
Risk-free interest rate		1.6%	-	3.0%			0.9%	-	1.3%
Expected volatility		88%					90%
Expected dividend rate		0%					0%

Performance Shares [Member]

Notes Tables

Schedule of Share-Based Payment Award, Stock Options, Valuation Assumptions [Table Text Block]

		Year Ended December 31,
		2022				2021
Derived service period (in years)			—			2.3	–	2.6
Risk-free interest rate			—			1.5%
Expected volatility			—			90%
Expected dividend rate			—			0%

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