<SEC-DOCUMENT>0001437749-26-009657-index.html : 20260325
<SEC-HEADER>0001437749-26-009657.hdr.sgml : 20260325
<ACCEPTANCE-DATETIME>20260324191724
ACCESSION NUMBER:		0001437749-26-009657
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		21
FILED AS OF DATE:		20260325
DATE AS OF CHANGE:		20260324

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			TALPHERA, INC.
		CENTRAL INDEX KEY:			0001427925
		STANDARD INDUSTRIAL CLASSIFICATION:	PHARMACEUTICAL PREPARATIONS [2834]
		ORGANIZATION NAME:           	03 Life Sciences
		EIN:				412193603
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-294580
		FILM NUMBER:		26787945

	BUSINESS ADDRESS:	
		STREET 1:		1850 GATEWAY DRIVE
		STREET 2:		SUITE 175
		CITY:			SAN MATEO
		STATE:			CA
		ZIP:			94404
		BUSINESS PHONE:		650-216-3500

	MAIL ADDRESS:	
		STREET 1:		1850 GATEWAY DRIVE
		STREET 2:		SUITE 175
		CITY:			SAN MATEO
		STATE:			CA
		ZIP:			94404

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	ACELRX PHARMACEUTICALS INC
		DATE OF NAME CHANGE:	20080222
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>acrx20260324_s3.htm
<DESCRIPTION>FORM S-3
<TEXT>
Document 1 - file: acrx20260324_s3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>ex_936601.htm
<DESCRIPTION>EXHIBIT 5.1
<TEXT>
Document 2 - file: ex_936601.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>ex_936452.htm
<DESCRIPTION>EXHIBIT 23.1
<TEXT>
Document 3 - file: ex_936452.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>ex_936453.htm
<DESCRIPTION>EXHIBIT FILING FEES
<TEXT>
Document 4 - file: ex_936453.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.SCH
<SEQUENCE>5
<FILENAME>tlph-20251231.xsd
<DESCRIPTION>XBRL TAXONOMY EXTENSION SCHEMA
<TEXT>
Document 5 - file: tlph-20251231.xsd

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.DEF
<SEQUENCE>6
<FILENAME>tlph-20251231_def.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION DEFINITION LINKBASE
<TEXT>
Document 6 - file: tlph-20251231_def.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.LAB
<SEQUENCE>7
<FILENAME>tlph-20251231_lab.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION LABEL LINKBASE
<TEXT>
Document 7 - file: tlph-20251231_lab.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-101.PRE
<SEQUENCE>8
<FILENAME>tlph-20251231_pre.xml
<DESCRIPTION>XBRL TAXONOMY EXTENSION PRESENTATION LINKBASE
<TEXT>
Document 8 - file: tlph-20251231_pre.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>9
<FILENAME>cooley.jpg
<TEXT>
Document 9 - file: cooley.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>10
<FILENAME>logo.jpg
<TEXT>
Document 10 - file: logo.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>12
<FILENAME>R1.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 12 - file: R1.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>14
<FILENAME>R2.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 14 - file: R2.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>15
<FILENAME>R3.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 15 - file: R3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>16
<FILENAME>R4.htm
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 16 - file: R4.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>17
<FILENAME>report.css
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 17 - file: report.css

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>18
<FILENAME>Show.js
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 18 - file: Show.js

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>21
<FILENAME>FilingSummary.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 21 - file: FilingSummary.html

Document 21 - RAW XML: FilingSummary.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>JSON
<SEQUENCE>23
<FILENAME>MetaLinks.json
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 23 - file: MetaLinks.json

</DOCUMENT>
<DOCUMENT>
<TYPE>ZIP
<SEQUENCE>24
<FILENAME>0001437749-26-009657-xbrl.zip
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 24 - file: 0001437749-26-009657-xbrl.zip

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>25
<FILENAME>acrx20260324_s3_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 25 - file: acrx20260324_s3_htm.html

Document 25 - RAW XML: acrx20260324_s3_htm.xml

</DOCUMENT>
<DOCUMENT>
<TYPE>XML
<SEQUENCE>26
<FILENAME>ex_936453_htm.xml
<DESCRIPTION>IDEA: XBRL DOCUMENT
<TEXT>
Document 26 - file: ex_936453_htm.html

Document 26 - RAW XML: ex_936453_htm.xml

</DOCUMENT>
</SEC-DOCUMENT>