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Document And Entity Information
 12 Months Ended
Dec. 31, 2025
Document Information [Line Items]  
Document Type S-3
Entity Registrant Name TALPHERA, INC.
Entity Incorporation, State or Country Code DE
Entity Tax Identification Number 41-2193603
Entity Address, Address Line One 1850 Gateway, Suite 175
Entity Address, City or Town San Mateo
Entity Address, State or Province CA
Entity Address, Postal Zip Code 94404
City Area Code 650
Local Phone Number 216-3500
Entity Filer Category Non-accelerated Filer
Entity Emerging Growth Company false
Entity Small Business true
Entity Central Index Key 0001427925
Amendment Flag false