<SEC-DOCUMENT>0001193125-21-157815-index.html : 20210511
<SEC-HEADER>0001193125-21-157815.hdr.sgml : 20210511
<ACCEPTANCE-DATETIME>20210511172823
ACCESSION NUMBER:		0001193125-21-157815
CONFORMED SUBMISSION TYPE:	S-3
PUBLIC DOCUMENT COUNT:		8
FILED AS OF DATE:		20210511
DATE AS OF CHANGE:		20210511

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lyra Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001327273
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-3
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-256020
		FILM NUMBER:		21912607

	BUSINESS ADDRESS:	
		STREET 1:		480 ARSENAL STREET
		CITY:			WATERTOWN
		STATE:			MA
		ZIP:			02472
		BUSINESS PHONE:		617-373-4600

	MAIL ADDRESS:	
		STREET 1:		480 ARSENAL STREET
		CITY:			WATERTOWN
		STATE:			MA
		ZIP:			02472

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	480 Biomedical, Inc.
		DATE OF NAME CHANGE:	20120927

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Arsenal Vascular, Inc.
		DATE OF NAME CHANGE:	20110826

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Arsenal Medical, Inc.
		DATE OF NAME CHANGE:	20090414
</SEC-HEADER>
<DOCUMENT>
<TYPE>S-3
<SEQUENCE>1
<FILENAME>d74270ds3.htm
<DESCRIPTION>S-3
<TEXT>
Document 1 - file: d74270ds3.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-1.2
<SEQUENCE>2
<FILENAME>d74270dex12.htm
<DESCRIPTION>EX-1.2
<TEXT>
Document 2 - file: d74270dex12.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-4.3
<SEQUENCE>3
<FILENAME>d74270dex43.htm
<DESCRIPTION>EX-4.3
<TEXT>
Document 3 - file: d74270dex43.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>4
<FILENAME>d74270dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 4 - file: d74270dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.2
<SEQUENCE>5
<FILENAME>d74270dex232.htm
<DESCRIPTION>EX-23.2
<TEXT>
Document 5 - file: d74270dex232.htm

</DOCUMENT>
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<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g74270g52p90.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g74270g52p90.jpg

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<TYPE>GRAPHIC
<SEQUENCE>7
<FILENAME>g74270g86u57.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 7 - file: g74270g86u57.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>8
<FILENAME>g74270g97j09.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 8 - file: g74270g97j09.jpg

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