    <SEC-DOCUMENT>0001564590-22-016097-index.html : 20220427
    <SEC-HEADER>0001564590-22-016097.hdr.sgml : 20220427
    <ACCEPTANCE-DATETIME>20220427163521
    ACCESSION NUMBER:		0001564590-22-016097
    CONFORMED SUBMISSION TYPE:	DEFA14A
    PUBLIC DOCUMENT COUNT:		3
    FILED AS OF DATE:		20220427
    DATE AS OF CHANGE:		20220427

    FILER:

    	COMPANY DATA:
    		COMPANY CONFORMED NAME:			Lyra Therapeutics, Inc.
    		CENTRAL INDEX KEY:			0001327273
    		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
    		IRS NUMBER:				000000000
    		STATE OF INCORPORATION:			DE
    		FISCAL YEAR END:			1231

    	FILING VALUES:
    		FORM TYPE:		DEFA14A
    		SEC ACT:		1934 Act
    		SEC FILE NUMBER:	001-39273
    		FILM NUMBER:		22860285

    	BUSINESS ADDRESS:
    		STREET 1:		480 ARSENAL WAY
    		CITY:			WATERTOWN
    		STATE:			MA
    		ZIP:			02472
    		BUSINESS PHONE:		617-373-4600

    	MAIL ADDRESS:
    		STREET 1:		480 ARSENAL WAY
    		CITY:			WATERTOWN
    		STATE:			MA
    		ZIP:			02472

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	480 Biomedical, Inc.
    		DATE OF NAME CHANGE:	20120927

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Arsenal Vascular, Inc.
    		DATE OF NAME CHANGE:	20110826

    	FORMER COMPANY:
    		FORMER CONFORMED NAME:	Arsenal Medical, Inc.
    		DATE OF NAME CHANGE:	20090414
    </SEC-HEADER>
    <DOCUMENT>
    <TYPE>DEFA14A
    <SEQUENCE>1
    <FILENAME>lyra-defa14a_20220616.htm
    <DESCRIPTION>DEFA14A
    <TEXT>
    Document 1 - file: lyra-defa14a_20220616.htm

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>2
    <FILENAME>gqidinxh3iav000002.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 2 - file: gqidinxh3iav000002.jpg

    </DOCUMENT>
    <DOCUMENT>
    <TYPE>GRAPHIC
    <SEQUENCE>3
    <FILENAME>gqidinxh3iav000001.jpg
    <DESCRIPTION>GRAPHIC
    <TEXT>
    Document 3 - file: gqidinxh3iav000001.jpg

    </DOCUMENT>
    </SEC-DOCUMENT>