<SEC-DOCUMENT>0001193125-24-074572-index.html : 20240322
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<ACCEPTANCE-DATETIME>20240322074139
ACCESSION NUMBER:		0001193125-24-074572
CONFORMED SUBMISSION TYPE:	S-8
PUBLIC DOCUMENT COUNT:		6
FILED AS OF DATE:		20240322
DATE AS OF CHANGE:		20240322
EFFECTIVENESS DATE:		20240322

FILER:

	COMPANY DATA:	
		COMPANY CONFORMED NAME:			Lyra Therapeutics, Inc.
		CENTRAL INDEX KEY:			0001327273
		STANDARD INDUSTRIAL CLASSIFICATION:	SURGICAL & MEDICAL INSTRUMENTS & APPARATUS [3841]
		ORGANIZATION NAME:           	08 Industrial Applications and Services
		IRS NUMBER:				000000000
		STATE OF INCORPORATION:			DE
		FISCAL YEAR END:			1231

	FILING VALUES:
		FORM TYPE:		S-8
		SEC ACT:		1933 Act
		SEC FILE NUMBER:	333-278164
		FILM NUMBER:		24773106

	BUSINESS ADDRESS:	
		STREET 1:		480 ARSENAL WAY
		CITY:			WATERTOWN
		STATE:			MA
		ZIP:			02472
		BUSINESS PHONE:		617-373-4600

	MAIL ADDRESS:	
		STREET 1:		480 ARSENAL WAY
		CITY:			WATERTOWN
		STATE:			MA
		ZIP:			02472

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	480 Biomedical, Inc.
		DATE OF NAME CHANGE:	20120927

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Arsenal Vascular, Inc.
		DATE OF NAME CHANGE:	20110826

	FORMER COMPANY:	
		FORMER CONFORMED NAME:	Arsenal Medical, Inc.
		DATE OF NAME CHANGE:	20090414
</SEC-HEADER>
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<TYPE>S-8
<SEQUENCE>1
<FILENAME>d808046ds8.htm
<DESCRIPTION>S-8
<TEXT>
Document 1 - file: d808046ds8.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-5.1
<SEQUENCE>2
<FILENAME>d808046dex51.htm
<DESCRIPTION>EX-5.1
<TEXT>
Document 2 - file: d808046dex51.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-23.1
<SEQUENCE>3
<FILENAME>d808046dex231.htm
<DESCRIPTION>EX-23.1
<TEXT>
Document 3 - file: d808046dex231.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>EX-FILING FEES
<SEQUENCE>4
<FILENAME>d808046dexfilingfees.htm
<DESCRIPTION>EX-FILING FEES
<TEXT>
Document 4 - file: d808046dexfilingfees.htm

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>5
<FILENAME>g808046dsp.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 5 - file: g808046dsp.jpg

</DOCUMENT>
<DOCUMENT>
<TYPE>GRAPHIC
<SEQUENCE>6
<FILENAME>g808046g0320043701337.jpg
<DESCRIPTION>GRAPHIC
<TEXT>
Document 6 - file: g808046g0320043701337.jpg

</DOCUMENT>
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